Adult Medication

Brand Names: US

Cabometyx; Cometriq


  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract or fistulas have happened with this drug. Talk with the doctor.
  • Very bad and sometimes deadly bleeding problems have happened with this drug. Talk with the doctor.
  • If you have bleeding problems, talk with your doctor.
  • Call your doctor right away if you have any signs of bleeding problems, like bruising; black, tarry, or bloody stools; bleeding gums; blood in the urine; coughing up blood; cuts that take a long time to stop bleeding; feel dizzy; feeling very tired or weak; nosebleeds; pain or swelling; throwing up blood or throw up that looks like coffee grounds; or very bad headache.

What is this drug used for?

  • It is used to treat thyroid cancer.
  • It is used to treat kidney cancer.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to cabozantinib or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have active bleeding or you are at risk for very bad bleeding.
  • If you have had recent bleeding or coughing up blood.
  • If you have any of these health problems: High blood pressure or liver disease.
  • If you are taking St. John’s wort. Do not take St. John’s wort with this drug. This drug may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take this drug. You may also need to avoid breast-feeding for some time after your last dose. Talk with your doctor to see if you need to avoid breast-feeding after your last dose.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • This drug may affect how wounds heal. If you need to have surgery, you may need to stop this drug before surgery. Start taking it again after surgery as you have been told by your doctor. Talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • High blood pressure has happened with this drug. Have your blood pressure checked as you have been told by your doctor.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • Avoid grapefruit and grapefruit juice.
  • Do not switch between different forms of this drug without first talking with the doctor.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with this drug. Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
  • Blood clots have happened with this drug. Sometimes, blood clots like stroke have been deadly. Call your doctor right away if you have chest, arm, back, neck, or jaw pain or pressure; coughing up blood; numbness or weakness on 1 side of your body, trouble speaking or thinking, change in balance, or change in eyesight; shortness of breath; or swelling, warmth, or pain in the leg or arm.
  • Very bad jaw problems have happened with this drug. Have a dental exam before you start this drug. Take good care of your teeth. Talk with your doctor.
  • This drug may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
  • This drug may cause harm to the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust to prevent pregnancy while taking this drug and for 4 months after your last dose.
  • If you get pregnant while taking this drug or within 4 months after your last dose, call your doctor right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Sweating a lot.
  • Trouble walking.
  • Shortness of breath.
  • Very bad belly pain.
  • Coughing, gagging, or choking (mainly when eating or drinking).
  • Very loose stools (diarrhea).
  • Loose stools (diarrhea) that will not go away.
  • Feeling very tired or weak.
  • A big weight loss.
  • Skin wound that will not heal.
  • Jaw pain.
  • Very bad mouth irritation.
  • Mouth sores.
  • Not able to pass urine or change in how much urine is passed.
  • Redness or irritation of the palms of hands or soles of feet.
  • Trouble swallowing.
  • A burning, numbness, or tingling feeling that is not normal.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Feeling tired or weak.
  • Loose stools (diarrhea).
  • Belly pain.
  • Not hungry.
  • Weight loss.
  • Upset stomach or throwing up.
  • Hard stools (constipation).
  • Mouth irritation.
  • Change in taste.
  • Headache.
  • Joint pain.
  • Muscle spasm.
  • Dizziness.
  • Change in voice.
  • Dry skin.


  • Hair loss.
  • Change in color of hair.
  • Anxiety.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
  • Swallow whole. Do not chew, break, or crush.
  • Take with a full glass of water.
  • To gain the most benefit, do not miss doses.
  • Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.


  • Do not open the capsules.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it and go back to your normal time.
  • If it is less than 12 hours until the next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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