Pediatric Medication

Brand Names: US

DDAVP; DDAVP Rhinal Tube; Stimate

Brand Names: Canada

Apo-Desmopressin; DDAVP; DDAVP Melt; DDAVP Rhinyle; Nocdurna; Octostim; PMS-Desmopressin; Teva-Desmopressin

What is this drug used for?

  • It is used to help prevent bedwetting.
  • It is used to lower urine output.
  • It is used to treat diabetes insipidus.
  • It is used to treat hemophilia.
  • It is used to treat von Willebrand disease.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

All products:

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has kidney disease or your child has ever had low sodium levels.
  • If your child has a health problem that leads to sodium loss like adrenal gland problems, diarrhea, eating disorders like anorexia or bulimia, nausea, or vomiting that will not stop.
  • If your child is drinking more water than normal.

Oral-disintegrating tablet:

  • If your child has any of these health problems: Heart problems, liver problems, or type IIB von Willebrand disease.


  • If your child has type IIB von Willebrand disease.


  • If your child has a stuffy nose, scarring on the inside of the nose, or trouble breathing through the nose.
  • If your child has had any recent nose surgery, injury, ulcers, or sores, talk with the doctor.


  • If your child has type IIB von Willebrand disease.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This drug may rarely cause very low sodium levels. If not treated, this can be deadly. Talk with the doctor.
  • Talk with the doctor if your child has an infection, a fever, loose stools (diarrhea), or is throwing up. Talk with the doctor if your child will be out in very hot weather, will be active, or will be changing how much water he/she drinks for any reason.
  • Very bad allergic reactions have rarely happened. Sometimes, allergic reactions have been deadly with the shot form of this drug. Talk with the doctor.
  • Use with care in children. Talk with the doctor.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low sodium levels like headache, trouble focusing, memory problems, feeling confused, weakness, seizures, or change in balance.
  • Very bad headache.
  • Upset stomach or throwing up.
  • Muscle pain or weakness.
  • Muscle spasm.
  • Feeling tired or weak.
  • Mood changes.
  • Change in the way your child acts.
  • Hallucinations (seeing or hearing things that are not there).
  • Restlessness.
  • Not hungry.
  • Shortness of breath, a big weight gain, swelling in the arms or legs.
  • Very bad dizziness or passing out.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Chest pain or pressure or a fast heartbeat.
  • Coughing up blood.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, or blurred eyesight.
  • A heartbeat that does not feel normal.


  • Bad nosebleeds.


  • Irritation or swelling where the shot was given.
  • Pain where the shot was given.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:

All products:

  • Flushing.
  • Runny nose.
  • Stuffy nose.


  • Cough.
  • Nosebleed.
  • Sore throat.

Oral and shot:

  • Headache.
  • Upset stomach.
  • Stomach cramps.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Follow what the doctor said about how much liquid to drink and how much to work out.

All oral products:

  • Give this drug with or without food.
  • Give at bedtime for bedwetting.

Oral-disintegrating tablet:

  • Do not push the tablet out of the foil when opening.
  • Do not remove the tablet from the tablet pack until you are ready to put in this drug. Put in the tablet right away after opening the blister pack. Do not store the removed tablet for future use.
  • Be sure your hands are dry before you touch this drug.
  • Place under your child’s tongue and let melt all the way before swallowing. Do not let your child chew, suck, or swallow the tablet.


  • Follow how to give this drug as you have been told by your child’s doctor or read the package insert.
  • Do not give this drug by mouth. Use in your child’s nose only. Keep out of your child’s mouth and eyes (may burn).
  • Have your child blow nose before use.

Nose spray:

  • Some products may have different ways to prime the pump. Some pumps may also need to be primed if not used for different periods of time. Follow how and when to prime as you have been told.


  • It is given as a shot into a vein or into the fatty part of the skin.

What do I do if my child misses a dose?


  • Call your doctor to find out what to do.

All other products:

  • Give a missed dose as soon as you think about it.
  • If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
  • Do not give 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

All oral products:

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.

Oral-disintegrating tablet:

  • Store in original container.

DDAVP® nose spray and Stimate®:

  • Store upright at room temperature. Do not freeze.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.


  • Throw away any part not used after 6 months.


  • Store in a refrigerator or at room temperature. If stored at room temperature, throw away any part not used after 3 weeks.
  • Store upright with the cap on.
  • Do not freeze.

DDAVP® Rhinal Tube:

  • Store in a refrigerator or at room temperature. If stored at room temperature, throw away any part not used after 3 weeks.
  • Do not freeze.


  • If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.

All products:

  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date



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