Pediatric Medication

Brand Names: US


Brand Names: Canada



  • Very bad and sometimes deadly meningococcal infections have happened in patients who have taken this drug. This type of infection can happen right away and be deadly if not treated early. Be sure your child gets a meningococcal vaccine at least 2 weeks before starting this drug unless the doctor tells you otherwise. Talk with the doctor.
  • You may only get this drug through a special program. Talk with your doctor.

What is this drug used for?

  • It is used to treat a blood and kidney disease called atypical hemolytic uremic syndrome (aHUS).
  • It is used to treat a blood disease called paroxysmal nocturnal hemoglobinuria (PNH).

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to eculizumab or any other part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child did not get a meningococcal vaccine.
  • If your child has a meningococcal infection.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • Make sure your child is up to date with all vaccines.
  • Vaccines lower the risk of infections; they do not get rid of the risk of infections. Talk with the doctor.
  • Have your child’s patient safety card with you at all times and for 3 months after drug is stopped.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • Some patients have very bad side effects during the infusion. Tell your child’s doctor if your child has any bad effects during the infusion.
  • Some health problems may happen after this drug is stopped. Your child will need to be watched closely for several weeks after stopping this drug. Follow up with the doctor as you have been told. After your child stops this drug, call the doctor right away if your child has a change in how much urine is passed; dark urine; swelling, warmth, or pain in the leg or arm; chest pain or pressure; coughing up blood; trouble breathing; weakness on 1 side of the body, trouble speaking or thinking, change in balance, or change in eyesight; change in thinking clearly and with logic; any bruising or bleeding that is not normal; or seizures.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of a meningococcal infection like very bad headache with or without upset stomach, throwing up, fever, or stiff neck or back; change in thinking clearly and with logic; high fever; fever with a rash; if light bothers the eyes; or very bad muscle aches or pain with or without flu-like signs.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Chest pain.
  • Not able to pass urine or change in how much urine is passed.
  • A fast heartbeat.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Swelling in the arms or legs.
  • Feeling very tired or weak.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Feeling tired or weak.
  • Runny nose.
  • Back pain.
  • Nose and throat irritation.
  • Headache.
  • Belly pain.
  • Not able to sleep.
  • Hard stools (constipation).
  • Muscle or joint pain.
  • Pain in arms or legs.
  • Muscle spasm.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
  • It is given as an infusion into a vein over a period of time.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date



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