Endometrial Biopsy

This information describes what to expect during and after your endometrial biopsy.

During Your Procedure

You will have your endometrial biopsy done in an exam room. You will lie on your back with your feet in stirrups. This is the same position you’re in for routine pelvic exams. You will be awake for the procedure. 

First, your doctor will put a speculum into your vagina. A speculum is a tool that will gently spread apart your vaginal walls so your doctor can see your cervix (the bottom part of your uterus). 

Next, your doctor will clean your cervix with a cool, brown solution of povidone-iodine (Betadine®). Then, they will put a thin, flexible tool through your cervix and into your uterus to take a small amount of tissue from your endometrium. You will feel some cramping as the tissue is removed. After the tissue is removed, your doctor will remove the speculum.

The procedure usually takes about 5 minutes. 

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After Your Procedure

  • You may have a small amount of vaginal spotting or bleeding. This may last for several days after your procedure. You may use a sanitary pad, if needed. Don’t use tampons.
  • You may have some cramping after your procedure. You can take medications such as ibuprofen (Advil®) or acetaminophen (Tylenol®).
  • Don’t place anything in your vagina for 48 hours unless your doctor tells you it’s okay. This includes douches and tampons.
  • Speak with your doctor or nurse about when it’s safe for you to resume vaginal intercourse.
  • Your doctor’s office will contact you with the biopsy results in about 1 week. 
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