This information describes what to expect during and after your endometrial biopsy.

During your endometrial biopsy, your doctor will remove a small piece of tissue from the lining of your uterus (endometrium). This tissue is then sent to the pathology department to be examined under a microscope to look for abnormal cells or signs of cancer.

The procedure usually takes about 5 minutes.

Before Your Procedure

Tell your doctor or nurse if:

  • You are allergic to iodine.
  • You are allergic to latex.
  • There is a chance that you may be pregnant. If you still get your period, you will need to take a urine pregnancy test. 

You do not need to do anything to prepare for this procedure.

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During Your Procedure

Your doctor will do the endometrial biopsy in an exam room. You will lie on your back with your feet in stirrups. This is the same position you are in for routine pelvic exams.

Your doctor will put a speculum into your vagina. The speculum is an instrument that will gently spread apart your vaginal walls so that your doctor can see your cervix.

Your doctor will clean your cervix with a cool, brown solution of povidone-iodine (Betadine®). He or she will put a thin, flexible tool through the speculum into your uterus and take a small amount of tissue from your endometrium. You will feel some cramping as the tissue is removed.

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After Your Procedure

  • You may have a small amount of vaginal spotting or bleeding. This may last for several days after the procedure. You may use a sanitary pad, if needed.
  • You can take over-the-counter medication for the cramping such as ibuprofen (Advil®) or acetaminophen (Tylenol®).
  • Do not place anything in your vagina for 48 hours unless your doctor tells you differently. This includes douches and tampons.
  • Speak with your doctor or nurse about when it is safe for you to resume vaginal intercourse.
  • Your biopsy results will be ready in about 1 week.
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Call Your Doctor or Nurse if You Have:

  • A temperature of 101° F (38.3° C) or higher
  • Vaginal bleeding that is heavier than your menstrual flow
  • Pain that does not get better after taking medication for cramping
  • Any unexpected problems
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