Carac; Efudex; Fluoroplex; Tolak
- It is used to treat a precancerous skin problem called actinic keratosis.
- If you have an allergy to fluorouracil or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have dihydropyrimidine dehydrogenase deficiency.
- If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
- If you are breast-feeding. Do not breast-feed while you take this drug.
- Tell dentists, surgeons, and other doctors that you use this drug.
- It may take a few months to see the full effect.
- Skin may look worse before it looks better.
- You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
- Talk with your doctor before you use other drugs or products on your skin.
- Most people using this drug get skin reactions where this drug is used. These reactions include burning, dryness, irritation, redness, pain, and swelling. Irritation may last for 2 weeks or longer after you stop using this drug. Call your doctor if you get a skin reaction that bothers you.
- The chance of very bad and sometimes deadly side effects is raised in patients who do not have the enzyme dihydropyrimidine dehydrogenase (DPD) in the body. These include mouth irritation or sores, loose stools (diarrhea), low white blood cell counts, or nerve problems. Talk with the doctor.
- This drug may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this drug, call your doctor right away.
- Use birth control that you can trust to prevent pregnancy during care. You may also need to use birth control for some time after care ends. Talk with your doctor to see if you need to use birth control after you stop this drug.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Very bad belly pain or bloody loose stools.
- Throwing up.
- Very loose stools (diarrhea).
- Change in eyesight, eye pain, or very bad eye irritation.
- Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
- Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
- Clean affected part before use. Make sure to dry well.
- Wait 10 minutes after washing affected part before putting drug on skin.
- Put a thin layer on the affected skin and rub in gently.
- Do not use coverings (bandages, dressings) unless told to do so by the doctor.
- Do not put on cuts, scrapes, eczema, or damaged skin.
- If you get this drug in the eyes, flush right away with cool water and get medical help.
- Put on a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not put on 2 doses or extra doses.
- Store at room temperature. Do not freeze.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call 212-639-2000.
Fluorouracil (Topical)©2016 Memorial Sloan Kettering Cancer Center - Generated on February 6, 2016