Hydroxyurea

Adult Medication

Brand Names: US

Droxia; Hydrea; Siklos

Brand Names: Canada

Hydrea

Warning

  • This drug may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, a wound that will not heal; any bruising or bleeding; or if you feel very tired or weak.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This drug may raise the chance of getting cancer. A type of cancer called leukemia and skin cancer have happened in people taking this drug for a long time. You will need to have regular check-ups. Your doctor will tell you how often to have these. Talk with the doctor.
  • Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.

What is this drug used for?

  • It is used to treat a type of leukemia.
  • It is used to treat cancer of the head and neck.
  • It is used to treat sickle cell anemia.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to hydroxyurea or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Anemia (other than sickle cell anemia); bone marrow problems like low platelet count, low red blood cell count, or low white blood cell count; or wounds on the legs (leg ulcers).
  • If you are taking any of these drugs: Didanosine or stavudine.
  • If you are breast-feeding. Do not breast-feed while you take this drug.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
  • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of an infection or make the vaccine not work as well.
  • In people who have HIV, very bad and sometimes deadly pancreas, liver, and nerve problems have happened when this drug was taken with certain other drugs. Talk with the doctor.
  • If you have had or will be having radiation treatment, talk with your doctor. Worse side effects from radiation treatment have happened with this drug.
  • Allergic reactions have happened with this drug. Sometimes, these have been very bad and people have had to go to the hospital. Talk with the doctor.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • This drug may affect sperm in men. This may affect being able to father a child. Talk with the doctor.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for some time after care ends. Use birth control that you can trust. Talk with your doctor to see how long to use birth control after you stop this drug.
  • If you are a man and your sex partner gets pregnant while you take this drug or within several months after your last dose, call your doctor right away.
  • This drug may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting this drug. Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking this drug and for 6 months after stopping this drug.
  • If you get pregnant while taking this drug or within 6 months after your last dose, call your doctor right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Change in color or size of a mole.
  • A skin lump or growth.
  • Feeling very tired or weak.
  • Change in skin or finger nails.
  • Skin ulcers and dead body tissue (gangrene) has happened with this drug. Call your doctor right away if you have skin ulcers or any other skin changes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Hair loss.
  • Upset stomach.
  • Not hungry.
  • Constipation.
  • Loose stools (diarrhea).
  • Headache.
  • Mouth sores.
  • Weight gain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Take this drug at the same time of day.
  • Take with or without food.
  • Take with a full glass of water.
  • Wash your hands before and after use.
  • To gain the most benefit, do not miss doses.
  • Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
  • You will need to take special care when handling this drug. Check with the doctor or pharmacist to see how to handle this drug.
  • Wear gloves when touching this drug.

Capsules:

  • Swallow whole. Do not chew or crush.
  • Do not open the capsules.
  • If the capsule is opened or broken, do not touch the contents. If the contents are touched or they get in the eyes, wash hands or eyes right away.

Tablets:

  • The 1000 mg tablets may be split. If using 100 mg tablets, do not split the tablets into smaller parts.
  • If you cannot swallow tablets, they can be dissolved in a small amount of water in a teaspoon. After mixing, take your dose right away. Do not store for future use.
  • If a tablet is crushed, do not touch it. If a crushed tablet is touched or gets it in the eyes, wash hands or eyes right away.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

All products:

  • Store at room temperature.
  • Keep lid tightly closed.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Capsules:

  • You must handle and throw away this drug the right way. If powder from the capsule is spilled, wipe it up with a damp paper towel. Throw away the towel and the empty capsules in a closed holder, such as a plastic bag. Wash your hands fully.

Tablets:

  • If using the 1000 mg tablets and you have split them, store the smaller parts in the bottle. Use the smaller parts within 3 months.
  • You must handle and throw away this drug the right way. If powder from a broken tablet is spilled, wipe it up with a damp paper towel. Throw away the towel in a closed holder, such as a plastic bag. Wash your hands fully.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2018-05-04

Copyright

© 2018 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.

Last Updated