Ketoconazole (Systemic)

Pediatric Medication

Brand Names: Canada

Apo-Ketoconazole; Teva-Ketoconazole

Warning

  • This drug must only be used when other drugs cannot be used or have not worked. Talk with your child’s doctor to be sure that the benefits of this drug are more than the risks.
  • Very bad and sometimes deadly liver problems like the need for a liver transplant have happened with this drug. Some people did not have a raised chance of liver problems before taking this drug. Most of the time, but not always, liver problems have gone back to normal after this drug was stopped. Call your child’s doctor right away if your child has signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Blood tests will be needed to watch for any liver problems. Talk with your child’s doctor.
  • Taking this drug with certain other drugs may raise the chance of very bad and sometimes deadly heart problems like a heartbeat that is not normal. Do not give this drug to your child if he/she is taking any of these drugs: Cisapride, disopyramide, dofetilide, dronedarone, methadone, pimozide, quinidine, or ranolazine.

What is this drug used for?

  • It is used to treat fungal infections.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has any of these health problems: A fungal infection of the brain or liver disease.
  • If your child is taking any of these drugs: Alprazolam, dihydroergotamine, eplerenone, ergonovine, ergotamine, felodipine, irinotecan, lovastatin, lurasidone, methylergonovine, methysergide, nisoldipine, oral midazolam, simvastatin, tolvaptan, or triazolam.
  • If your child takes colchicine and also has kidney or liver problems.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • Have your child avoid tasks or actions that call for alertness until you see how this drug affects your child. These are things like riding a bike, playing sports, or using items such as scissors, lawnmowers, electric scooters, toy cars, or motorized vehicles.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • If your child has high blood sugar (diabetes), talk with the doctor. This drug may lower blood sugar. High blood sugar drugs may need to be changed.
  • Do not give to your child longer than you have been told. A second infection may happen.
  • Alcohol may interact with this drug. Be sure your child does not drink alcohol.

If your child is or may be sexually active:

  • This drug may lower testosterone levels. This may cause a change in sex ability, enlarged breasts, or low sperm counts. Testosterone levels go back to normal after this drug is stopped. Talk with the doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Be sure your child uses some other kind of birth control also, like a condom, when taking this drug.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Bloating.
  • Low mood (depression).
  • If your child is planning to harm him/herself. If the want to harm him/herself gets worse.
  • A heartbeat that does not feel normal.
  • Fever or chills.
  • Sore throat.
  • A burning, numbness, or tingling feeling that is not normal.
  • Swelling in the arms or legs.
  • Swelling of belly.
  • Any bruising or bleeding.
  • Change in eyesight.
  • Feeling very tired or weak.
  • Very upset stomach or throwing up.
  • Dizziness.
  • Chest pain or pressure, a fast heartbeat, or passing out.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Belly pain.
  • Upset stomach.
  • Loose stools (diarrhea).
  • Headache.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
  • To gain the most benefit, do not miss giving your child doses.
  • Give as you have been told, even if your child feels well.
  • Give this drug at the same time of day.
  • Give this drug with or without food.
  • Talk with the doctor if your child is also taking antacids, cimetidine, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, pantoprazole, rabeprazole, or ranitidine. Your child may need to take this drug with an acidic drink like non-diet cola.
  • Do not give your child aluminum hydroxide within 1 hour before or 2 hours after your child takes this drug.

What do I do if my child misses a dose?

  • Give a missed dose as soon as you think about it.
  • If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
  • Do not give 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2015-05-15

Copyright

© 2015 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call 212-639-2000.
Ketoconazole (Systemic)
©2015 Memorial Sloan Kettering Cancer Center - Generated on July 28, 2015