- It is used to treat constipation caused by some pain drugs.
- If you have an allergy to methylnaltrexone or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have ever had bowel block.
- If you are taking or will be taking another drug like this one.
- If you are breast-feeding. Do not breast-feed while you take this drug.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Be sure to stay close to a bathroom after you use this drug. Most people have a stool within a few minutes to a few hours after using it.
- Talk with your doctor before using a laxative with this drug.
- This drug is only for use in patients who take pain drugs. Tell your doctor if you stop taking your pain drug.
- Signs of opioid withdrawal have happened with this drug. Call your doctor right away if you have more sweating, chills, loose stools (diarrhea) or stomach pain that is not normal, anxiety, irritability, or yawning.
- This drug may not work as well for people who have been taking pain drugs for less than 4 weeks.
- If you are 65 or older, use this drug with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- If this drug is used during pregnancy, it may cause withdrawal in the unborn baby. A doctor will need to check on the unborn baby after this drug is used.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very loose stools (diarrhea).
- Loose stools (diarrhea) that will not go away.
- Tears in the stomach or bowel wall have happened in certain people taking this drug. Call your doctor right away if you have swelling or pain in your stomach that is very bad, gets worse, or does not go away. Call your doctor right away if you throw up blood or have throw up that looks like coffee grounds; upset stomach or throwing up that does not go away; or black, tarry, or bloody stools.
- Belly pain.
- Loose stools (diarrhea).
- Sweating a lot.
- Feeling full.
- Muscle spasm.
- Runny nose.
- Upset stomach.
- Take on an empty stomach. Take at least 30 minutes before the first meal of the day.
- Take with a full glass of water.
- It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Follow how to use as you have been told by the doctor or read the package insert.
- Wash your hands before and after use.
- Move the site where you give the shot with each shot.
- Do not give into red or irritated skin.
- Do not use if the solution is cloudy, leaking, or has particles.
- This drug is colorless to a faint yellow. Do not use if the solution changes color.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- If you take this drug on a regular basis, take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Many times this drug is taken on an as needed basis. Do not take more often than told by the doctor.
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Store in the original container. Do not take out the antimoisture cube or packet.
- Do not freeze.
- Protect from light.
- If this drug is drawn from a vial into a syringe, it may be stored in the syringe at room temperature for up to 24 hours.
- Throw away any part of opened vial not used after use.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.