Pediatric Medication

Brand Names: US


Brand Names: Canada



  • Very bad and sometimes deadly side effects have rarely happened during and within 24 hours after the infusion. Tell the doctor if your child has any bad effects during or within 24 hours after the infusion.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if your child has signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes.
  • If your child has had hepatitis B before or carries the virus, this drug can cause the virus to become active. This can lead to very bad and sometimes deadly liver problems. Your child will be tested for hepatitis B before starting this drug, while on this drug, and for a few months after this drug is stopped. Do not give this drug to your child if your child has active hepatitis liver disease.
  • A very bad brain problem called progressive multifocal leukoencephalopathy (PML) may happen with this drug. It may cause disability or death. Tell the doctor right away if your child has signs like confusion, memory problems, low mood (depression), change in the way your child acts, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.

What is this drug used for?

  • It is used to treat blood problems.
  • It is used to treat a type of lymphoma.
  • It may be used to treat graft-versus-host-disease (GVHD).
  • It is used to treat diseases of the immune system.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to mouse proteins, talk with the doctor.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has an infection.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • Very bad and sometimes deadly infections can happen with this drug. Talk with the doctor.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • If your child is taking this drug for rheumatoid arthritis, make sure your child is up to date with all vaccines.

If your child is or may be sexually active:

  • Have your child use birth control to prevent pregnancy while taking this drug and for 12 months after stopping this drug.

If your child is pregnant or breast-feeding a baby:

  • If your child gets pregnant while taking this drug or within 12 months after her last dose, call the doctor right away.
  • Tell the doctor if your child is breast-feeding a baby. You will need to talk about any risks to the baby.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Dizziness or passing out.
  • Feeling very tired or weak.
  • Very bad headache.
  • Any unexplained bruising or bleeding.
  • Kidney problems have happened with this drug in people with lymphoma. Sometimes, these have been deadly. Call the doctor right away if your child is unable to pass urine, has blood in the urine, or has a change in the amount of urine passed.
  • People who took this drug with some cancer drugs have had bowel block or tears in the bowel. Sometimes this has been deadly. Call the doctor right away if your child has very bad belly pain; very hard stools (constipation); throwing up, throwing up blood, or throw up that looks like coffee grounds; or black, tarry, or bloody stools.
  • Patients with cancer who take this drug may be at greater risk of getting a bad and sometimes deadly health problem called tumor lysis syndrome (TLS). Call your child’s doctor right away if your child has a fast heartbeat; a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools, or not able to eat; or feel sluggish.
  • Heart failure has rarely happened in people taking this drug. Sometimes, this has been deadly. Call your child’s doctor right away if your child has shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Very bad and sometimes deadly lung problems have happened with this drug. Call the doctor right away if your child has lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Headache.
  • Belly pain.
  • Runny nose.
  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Dizziness.
  • Loose stools (diarrhea).
  • Muscle spasm.
  • Muscle or joint pain.
  • Back pain.
  • Not able to sleep.
  • Night sweats.
  • Throat irritation.
  • Flushing.
  • Anxiety.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
  • It is given as a shot into a vein over a period of time.
  • Other drugs may be given before this drug to help avoid side effects.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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