Expertise To Treat Metaplastic Breast Cancer From MSK’s Rare Breast Cancer Program

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Photo of Hispanic patient who had metaplastic breast cancer.

Michelle Villagomez says MSK’s Rare Breast Cancer team helped her through her treatment for metaplastic breast cancer. “The nurses and doctors are all wonderful at letting you know they’ve seen it before.”

It all happened so fast, says Michelle Villagomez. During a mammogram in February 2022 to check out a grape-sized lump in her right breast, the medical staff told Michelle to stay for an ultrasound. Then the radiologist pulled her aside and urged her to see an oncologist.

“I walked to the parking lot and sat in my car to process that this was something serious,” Michelle recalls. She called her friend whose brother was a doctor in Long Island. He arranged a biopsy right away.

Then came the alarming result: She had metaplastic breast cancer, a rare, invasive form of the disease. The information about it online was frightening to Michelle, a then 41-year-old married mother of a 4-year-old. She held out hope that the diagnosis was wrong.

“There are some situations when you want to be special,” she says, “but when it comes to something like breast cancer, you want to have the run-of-the-mill type that doctors see all the time.”

To have the best prognosis (outcome) for metaplastic breast cancer, she wanted a second opinion from doctors who are familiar with rare types of breast cancer. Friends and co-workers recommended she call Memorial Sloan Kettering Cancer Center (MSK).

Michelle met with MSK breast surgeon Giacomo Montagna, who immediately eased her anxiety. “He has the best bedside manner, very kind and competent, which gave me confidence,” she says.

Surgery for Rare Breast Cancers, Like Metaplastic

Dr. Montagna is Co-Director of MSK’s Rare Breast Cancer Program, along with medical oncologist and breast cancer specialist Nour Abuhadra. Because there are so few cases, only a small number of doctors have experience in diagnosing and treating rare cancers like Michelle’s.

“Treatment guidelines are based on more common breast cancers, but we know each rare type is distinct,” Dr. Montagna says. “For rare tumors like metaplastic breast cancer, we have the expertise to deliver the best treatment. MSK patients often have access to experimental treatments before other patients.”

Looking at the biopsy, the doctors at MSK confirmed that Michelle had metaplastic breast cancer, also called metaplastic carcinoma. Dr. Montagna collaborated with breast cancer oncologist Pedram Razavi, an active member of the program, and reconstructive surgeon Jonas Nelson to develop the best treatment plan for Michelle.

Don't be afraid to ask questions or get a second opinion. I did and found out MSK is a wonderful place.
Michelle Villagomez

They initially proposed chemotherapy and immunotherapy to shrink the tumor, to be followed by surgery — an approach used for so-called triple-negative tumors, which do not express receptors for estrogen, progesterone, or HER2. These cancers can be harder to treat. Although Michelle’s tumor had very small levels of weak estrogen receptor (ER) expression, because it was metaplastic, the doctors treated it as if it were triple-negative.

“The idea is to be as aggressive as we can in the beginning to eradicate cancer cells that have already spread,” Dr. Razavi says. He wanted to start the chemotherapy right away. Dr. Razavi is also an expert in cancer genomics, which analyzes the genetic profile of a tumor to determine the best treatment.

Michelle’s tumor was growing even faster than expected. If it spread into the skin or chest wall, it could become inoperable. Drs. Razavi and Montagna agreed immediate surgery was needed. They explained to Michelle the various surgical options, including not only removing the tumor but also breast reconstruction to achieve the best cosmetic result.

Rare Breast Cancer
A diagnosis of a rare breast cancer means you have a type of breast cancer that is not common. Out of every 100 people with breast cancer, 5 cases are a rare subtype. Because there are so few cases, only some doctors have experience in diagnosing and treating them. It’s important to choose a care team that is trained in treating rare breast cancers.
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Nipple-Sparing Mastectomy After Rare Breast Cancer Diagnosis

Michelle opted to have a nipple-sparing mastectomy, a procedure that leaves the nipple and areola intact, along with the breast skin. In late March, Drs. Montagna and Nelson did the procedure in a single operation at the Josie Robertson Surgery Center. Dr. Montagna removed the entire breast while retaining the nipple. He also removed the first few lymph nodes in the armpit to test for the presence of cancer cells.

Through the same skin incision, Dr. Nelson inserted a temporary implant called a tissue expander. This hollow implant is gradually inflated over time, stretching the skin to make room for a more permanent breast implant about six months later, if Michelle chooses to have one.

“The scar is in a place where it is hidden, and it looks like nothing happened when I am fully dressed,” Michelle explains. She was discharged the day after surgery and recovered well. “I had never had surgery before, so the first few days were rough. But after the first week, it was manageable,” she says.

“Dr. Montagna really flipped the switch for me psychologically,” Michelle explains. “After the surgery, he said: ‘You do not have cancer right now. The tumor is out, and everything else we’re doing is to prevent recurrence.’ ”

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Using Chemotherapy and Immunotherapy To Treat Rare Breast Cancers

Dr. Razavi oversaw the next phase of treatment, starting Michelle on a regimen of four breast cancer chemotherapy drugs and an immunotherapy drug. Because her cancer was aggressive, the treatment had to be powerful.

“The benefit of our Rare Breast Cancer Program is that you need to deviate from the standard of care,” Dr. Razavi says. “I have several patients now with breast cancers that are very rare, including multiple patients with metaplastic cancer.”

He points out that other institutions might have treated Michelle’s cancer as if it were ER-positive, which would have resulted in undertreatment.

“This is one of the nuances of dealing with these rare tumors,” he says. “Based on our cumulative experience here at MSK, we have the expertise to consider the right treatment approach for not just rare types of breast cancer but subtypes within them. Sometimes it’s escalating treatment, but often it’s de-escalation — they may have a subtype that doesn’t need such strong therapy. These patients need a program with doctors subspecialized in pathology, clinical treatment, and genomic testing for such rare breast cancer subtypes.”

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Supportive Care for All People With Breast Cancer

“The MSK team really helped me go through this stressful time,” Michelle says. “Chemotherapy was a shock to my system. But I know at any time when I don’t feel well, I can call and someone will help me. The nurses and doctors are all wonderful at letting you know they’ve seen it before, and there’s no reason I have to feel bad — they can adjust medications to make it more tolerable.”

Michelle also was referred to an MSK social worker who counseled her on how to explain her condition to her young son. “I was very stressed about what to say — how would he react when my hair started falling out? But they helped guide me in demystifying the cancer experience and making things go smoothly. He was not thrilled when I was bald, but now he jokes about it.”

Now 42, Michelle is back to managing the household and working remotely for her job at an animal welfare nonprofit while she continues chemotherapy and immunotherapy. When those are finished in September 2022, Dr. Nelson will complete the breast reconstruction.

As part of the follow-up care, Dr. Razavi plans to do several “liquid biopsies,” which involve analyzing blood samples with very sensitive tests to look for cancer cells that may be circulating throughout the body. If there is evidence of microscopic disease, he may offer further treatment such as oral chemotherapy.

Today, Michelle enjoys family activities, especially finding new restaurants and trying new foods at home. “We focus on creating happy memories for our son — whether it’s a hike or just riding the trains around one day when that’s what he wanted.”

Michelle urges her friends to get their regular mammograms, after many had postponed them during the pandemic. A good friend followed her advice and was diagnosed with breast cancer — a more common type. At Michelle’s recommendation, she also was treated by Drs. Montagna and Nelson and is doing well.

“You should be your best advocate,” Michelle says. “Don’t be afraid to ask questions or get a second opinion. I did and found out MSK is a wonderful place.”

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