This information describes the common uses of AHCC, how it works, and its possible side effects.
Active Hexose Correlated Compound
How It Works
AHCC has immunomodulatory and anticancer effects. But large human studies are lacking.
Active hexose correlated compound (AHCC) is an extract of mushrooms from the Basidiomycete class, including shiitake mushrooms. This product contains polysaccharides called glucans, which scientists think are responsible for its biological activity. One study showed that it could enhance the activity of natural killer cells (a type of immune cell) in the test tube. Animal studies suggest that AHCC has antioxidant and anti-inflammatory effects, and can improve the response of the immune system in mice with chemotherapy-weakened immune systems. In humans, AHCC has been shown to improve liver function in patients with hepatocellular carcinoma and cirrhosis and reduce the levels of certain tumor markers in the blood.
To prevent and treat cancer
Laboratory studies show some anti-cancer activity, but these results are not especially strong. One human study supported the use of AHCC in patients undergoing surgical resection of hepatocellular carcinoma, but this study had design flaws and much more research is needed.
Another study found AHCC to be an ineffective treatment for early stage prostate cancer.
Do Not Take If
You are taking drugs that are substrates of Cytochrome P450 2D6 (AHCC can decrease the effects of such drugs).
Diarrhea and itching have been reported in patients following administration of AHCC.
If you have any questions or concerns, contact a member of your healthcare team directly or call 212-639-2000 for help.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call 212-639-2000.