Research Pharmacy

Raymond Muller (Core Head)

research pharmacy


The Research Pharmacy supports Memorial Sloan Kettering investigators in producing and formulating a variety of investigational agents – including small molecules, peptides, antibodies, vaccines, adjuvants, and viral vectors – that are given to animals or patients during research studies. The services we provide enable the translation of  investigational agents into therapeutic agents, making the process more rapid and effective.

Led by Raymond Muller, the service includes three principal units: the Pharmaceutical Product Service, the Clinical Grade Production service, and the Pharmacy Investigational Drug service.

Pharmaceutical Product Service

Led by Mark Klang (, this group is responsible for issues related to drug formulation, stability, and compatibility. Our services include, but are not limited to, formulation, analysis, and evaluation of drug release rates; predicting drug interactions; and determining the compatibility and physical stability of medications used in clinical investigations.

Back to top

Clinical Grade Production Service

The Clinical Grade Production service, led by Govind Ragupathi (, is a class 10,000 cGMP facility  responsible for the bulk product manufacture, purification, and characterization of clinical-grade materials. In addition, we offer vialing of sterile investigational products such as peptides, proteins, carbohydrates, and adjuvants. The service also conducts lot release tests – which are required for products  release for preclinical and investigational use — either in-house or with validated contract vendors.

Back to top

Pharmacy Investigational Drug Service

This unit, led by Gerald O’Neill (, provides a mechanism to develop, procure, prepare, and validate the preparation and packaging of investigational drugs for clinical use and distribution. The Pharmacy Investigational Drug Service reviews the labeling, packaging, and quantity of investigational agents and for accuracy compares this information with the manufacturing batch record, IRB protocol, and pharmacy computer setup.

Back to top