The Gene Editing & Screening Core Facility (GES Core, known as the RNAi Core Facility from 2013 to 2017) provides MSKCC investigators with two RNA-guided technologies, RNA Interference (RNAi) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), to study individual genes, dissect signaling pathways, and identify potential drug targets. The GES Core provides the investigators with individual clone and pooled library of shRNA (RNAi) and sgRNA (CRISPR). The GES Core also conducts pooled library screening of shRNA and sgRNA by next generation sequencing, cell line production with gene knock-in and knock-out, and arrayed library screening of a human full-genome siRNA and various compound libraries in microtiter plate format.