Hospital Research Teams

The Adriana Haimovitz-Friedman Lab


Adriana Haimovitz-Friedman, PhD
Adriana Haimovitz-Friedman, PhD

The focus of my laboratory is to understand how SDRT can initiate an innate response in the local tumor and also contribute to initiation of a response in distant tumors (Abscopal/Adscopal like effects).

In addition, we use combination of SDRT and chemotherapeutic drugs with short acting anti-angiogenic agents, which result in improved tumor response with less overall toxicity.

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The Adriana Haimovitz-Friedman Lab

Publications Highlights

Wang F, Li H, Markovsky E, Glass R, de Stanchina E, Powell SN, Schwartz GK, Haimovitz-Friedman A. Pazopanib radio-sensitization of human sarcoma tumors. Oncotarget. 2018 Feb 6;9(10):9311. doi: 10.18632/oncotarget.24281. eCollection 2018 Feb 6.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R. Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation. Cell Signal. 2017 Feb 24; 34:86-91. doi: 10.1016/j.cellsig.2017.02.021. [Epub ahead of print] PMID: 28238856. DOI: 10.1016/j.cellsig.2017.02.021

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN,    Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M. Tumour-specific PI3K inhibition via      nanoparticle-targeted delivery in head and neck squamous cell carcinoma. Nat Commun. 2017 Feb       13;8:14292. doi: 10.1038/ncomms14292. PMID: 28194032.

Jacobi J, Garcia-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Manova K, Fuks Z, Kolesnick R, Haimovitz-Friedman A. Targeting acid sphingomyelinase with anti-angiogenic chemotherapy. Cell Signal. 2016 Oct 1. pii: S0898-6568(16)30236-4. doi: 10.1016/j.cellsig.2016.09.010. [Epub ahead of print] PMID: 27702691

Mizrachi A, Cotrim AP, Katabi N, Mitchel JB, Verheij M, Haimovitz-Friedman A. Radiation-induced microvascular injury as a mechanism of salivary gland hypofunction and potential target for radioprotectors. Radiat Res. 2016 Aug; 186(2):189-95. doi: 10.1667/RR14431.1. PMID: 27459704

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Adriana Haimovitz-Friedman, PhD

Adriana Haimovitz-Friedman, PhD

  • Optimizing the use of Single high Dose Radiation Therapy (SDRT) in pre-clinical studies to activate innate immune signaling pathways, potentially leading to adaptive immune responses within the local tumors and in distant ones, i.e eliciting Adscopal and/or Abscopal effects.
[email protected]
Email Address
(646) 888-2172
Office Phone


Yang Bai

Weill Cornell PhD Student

Chloe Bodden

Lab Technician

Hongyan Li

Research Associate

Ela Markovsky, PhD
Ela Markovsky

Postdoctoral Research Fellow

Mickael Francois Mathieu, Research Fellow
Mickael Francois Mathieu

Research Fellow

Heerim Nam

Visiting Associate Attending Radiation Oncologist from Seoul, Korea

Prerna Nepali
Prerna Nepali

Research Scholar

Lab Affiliations


  • Our Laboratory was the first to discover that radiation can induced damage to the plasma membrane of the endothelial cells, which resulted in a paradigm shift in the treatments of radiation and introduced the Single high Dose Radiation therapy, SDRT, in the clinic, which results in cures for those tumors that are otherwise non-responders to conventional fractionated radiation therapy.
  • We found the optimal timing to combine SDRT with anti-angiogenics and with chemotherapy.
  • For both prostate and breast cancers, ATM down regulation can radiosensitize via a specific signal transduction pathway involving de novo ceramide generation.
  • Radiation-induced acute blood-brain barrier disruption is mediated by the acid sphingomyelinase (ASMase) pathway, a major contribution to the radiation and brain drug delivery field.
  • Mice suffering from sepsis can be rescued by protecting the microvasculature.
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  • Mice are protected from Radiation-induced gastrointestinal syndrome by protecting the microvasculature via inhibition of the ASMase/Ceramide pathway.

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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

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Adriana Haimovitz-Friedman discloses the following relationships and financial interests:

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