The Adriana Haimovitz-Friedman Lab: Publications

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Wang F, Li H, Markovsky E, Glass R, de Stanchina E, Powell SN, Schwartz GK, Haimovitz-Friedman A. Pazopanib radio-sensitization of human sarcoma tumors. Oncotarget. 2018 Feb 6;9(10):9311. doi: 10.18632/oncotarget.24281. eCollection 2018 Feb 6.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R. Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation. Cell Signal. 2017 Feb 24; 34:86-91. doi: 10.1016/j.cellsig.2017.02.021. [Epub ahead of print] PMID: 28238856. DOI: 10.1016/j.cellsig.2017.02.021

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN,    Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M. Tumour-specific PI3K inhibition via      nanoparticle-targeted delivery in head and neck squamous cell carcinoma. Nat Commun. 2017 Feb       13;8:14292. doi: 10.1038/ncomms14292. PMID: 28194032.

Jacobi J, Garcia-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Manova K, Fuks Z, Kolesnick R, Haimovitz-Friedman A. Targeting acid sphingomyelinase with anti-angiogenic chemotherapy. Cell Signal. 2016 Oct 1. pii: S0898-6568(16)30236-4. doi: 10.1016/j.cellsig.2016.09.010. [Epub ahead of print] PMID: 27702691

Mizrachi A, Cotrim AP, Katabi N, Mitchel JB, Verheij M, Haimovitz-Friedman A. Radiation-induced microvascular injury as a mechanism of salivary gland hypofunction and potential target for radioprotectors. Radiat Res. 2016 Aug; 186(2):189-95. doi: 10.1667/RR14431.1. PMID: 27459704

Book Chapters and Invited REVIEW articles

Treves AJ, Haimovitz A, Fuks Z. Changes in surface markers of human monocytes following their in vitro maturation to macrophages. In: Marcophages and natural killer cells. Ed. S.J. Norman and E Sorken. Plenum Press, NY 1982:227-232.

Rosenstreich D, Haimovitz A, Brown KM, Liao Z. Human interleukin 1 inhibitors.       Lymphokines, 1987; 14:63-89.

Vlodavsky I, Bashkin P, Ishai-Michaeli R, Chajek-Shaul T, Bar-Shavit R, Haimovitz-Friedman A, Klagsburn M, Fuks Z. Sequestration and release of Basic Fibroblast Growth Factor. In:  Baird A, Klagsburn M, eds. The Fibroblast Growth Factor Family. Ann. NY Academy of Science. 1991; 638:207-220.

Vlodavsky I, Eldor A, Haimovitz-Friedman A, Matzner Y, Ishai-Michaeli R, Levi E, Bashkin P, Lider O, Naparstek Y, Cohen RI, Fuks Z. Expression of heparanase by platelets and circulating cells of the immune system: Possible involvement in diapedesis and extravasation. Invasion & Metastasis. 1992; 12:112-127.

Weichselbaum RR, Fuks Z, Hallahan DE, Haimovitz-Friedman A, Kufe DW. Radiation induced cytokines and growth factors: cellular and molecular basis of the modification of radiation damage. In: Molecular Biology for Clinical Oncologist. Ed. J Yarnold, M Stratton and T McMillen Publisher: Elsevier Science. Amsterdam, The Netherlands. p213-231. 1993.

Hallahan DE, Haimovitz-Friedman A, Kufe DW, Fuks Z, Weichselbaum RR. The role of cytokines in radiation biology. In:  Important Advances in Oncology. Ed. VT DeVita, S Hellman and SA Rosenberg. JB Lippincott Co., Philadelphia. 1993:71-80.

Fuks Z, Haimovitz-Friedman A, Hallahan DE, Kufe DW, Weichselbaum RR. Stress Response Genes Induced in Mammalian Cells by Ionizing Radiation.  Rad. Onc. Inv. 1993; 1: 81-93.

Kolesnick RN, Haimovitz-Friedman A, Fuks Z. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem. Cell Biol. 1994; 72:471-474.

Fuks Z, Haimovitz-Friedman A, Kolesnick R. The role of sphingomyelin pathway and protein kinase C in radiation-induced cell kill. In: Important Advances in Oncology. Ed. VT DeVita, S Hellman and SA Rosenberg.  J B Lippincott Co., Philadelphia. 1995:19-31.

Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Modulation of the Apoptotic Response: Potentional for Improving the Outcome in Clinical Radiotherapy. Seminars in Radiation Oncology, 1996; 6:273-283.

Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Ceramide signaling in apoptosis. British Medical Bulletin, 1997; 53:539-553.

Haimovitz-Friedman A, Kolesnick RN, Fuks Z. Differential Inhibition of Radiation-Induced Apoptosis. Radiation Injury and the Chernobyl Catastrophe 1997; 15:43-47.

Haimovitz-Friedman A, Fuks Z. Signaling in the radiation response of endothelial cells. In:  Radiation Biology of the Endothelial Cell. Ed. DB Rubin.  CRC Press, Inc., Boca Raton, FL, 1998:101-127.

Haimovitz-Friedman A. Radiation-induced Signal Transduction and Stress Response. In: Radiation Research special issue commemorating the discovery of radium and polonium by Marie Curie in 1898. Radiat. Res. 1998; 150:S102-S108.

Verheij M, Ruiter GA, Zerp SF, van Blitterswijk WJ, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Bartelink H. The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis. Radiother Oncol 1998, 47:225-232.

Haimovitz-Friedman A, Yang, T-I J, Thin TH, Verheij, M. Imaging radiotherapy-induced apoptosis. Radiat Res 2012; 177:467-482.

Yang TJ, Haimovitz-Friedman A, Verheij M. Anticancer therapy and apoptosis imaging. Exp Oncol. 2012; 34:269-276.

Hajj C, Haimovitz-Friedman A. Spingolipids and Disease. Handbook of Experimental Pharmacology 216. 2013; Chapter 6.

Hajj C, Becker KA, Haimovitz-Friedman A. Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways. Biological Chemistry. ISSN (online) 1437-4315. DOI: 10.1515/hsz-2014-0302.

Haimovitz-Friedman, A. Preface: Nanotechnology in imaging and cancer therapy. Critical Reviews in Oncogenesis (2014) 19(3-4): V-VII.

Editor

Kasid U, Notario V, Haimovitz-Friedman A, Bar-Eli M. Reviews in Cancer Biology and Therapeutics 2007.

Haimovitz-Friedman A. Guest Editor for special issue in Journal of Critical Reviews in Oncogenesis, on “Nanotechnology in Imaging and Cancer Therapy,” 2014.

Original Publications

Laskov R, Rabinowitz R, Haimovitz A, Schlesinger M. Cell surface antigens as differentiation markers of the B. lymphocyte lineage. Israel Journal of Med. Sc.1977; 13: 767-776.

Treves AJ, Yagoda D, Haimovitz A, Rachmilewitz D, Fuks Z. The isolation and purification of human peripheral blood monocytes in cell suspension. J. of Immunol. Methods.1980; 39:71-80.

Treves AJ, Ligumski M, Fuks Z, Haimovitz A, Rachmilewitz D. Prostaglandin E2 secretion by subsets of human peripheral blood monocytes. Immunopharmacology. 1982; 82:673-679.

Haimovitz A, Fuks Z, Galili N, Treves AJ. Changes in peanut agglutinin binding to human monocytes during their maturation to macrophages. J. Res. 1982, 31:187-192.

Rachmilewitz D, Ligumsky M, Haimovitz A, Treves AJ. Prostanoid synthesis by cultured peripheral blood mononuclear cells in inflammatory disease of the bowel. Gastroenterology. 1982: 82: 673-679.

Haimovitz A, Fuks Z, Rubenstein M, Treves AJ. The instability of membrane markers expressed by human monocytes and marcophages in culture. Immunobiol. 1983; 165: 432-444.

Treves AJ, Haimovitz A, Halimi M, Fibach E, Fuks Z. Marker analysis of cloned     populations of human monocytes.  Exp. Hematol. 1985; 13:111-116.

Maoz H, Kaiser N, Halimi M, Barak V, Haimovitz A, Weinstein D, Simon A, Yagel S, Biran S, Treves AJ. The effect of estradiol on human myelomonocytic cells. 1. Enhancement of colony formation. J. Reproductive Immuno. 1985; 7:325-335.

Liao Z, Haimovitz A, Chen Y, Chan Y, Rosenstreich DL. Characterization of a human interleukin-1 inhibitor. J. Immunol. 1985; 134: 3882-3886.

Witte L, Fuks Z, Haimovitz-Friedman A, Vlodavsky I, Goodman DS, Eldor A. Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells. Cancer Res. 1989; 49:5066-5072.

Rogelj S, Klagsbrun M, Atzmon R, Kurokawa M, Haimovitz-Friedman A, Fuks Z, Vlodavsky I. Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC cells. J. Cell Biol. 1989; 109:823-831.

Cordon-Cardo C, Vlodavsky I, Haimovitz-Friedman A, Hicklin D, Fuks Z. Expression of Basic fibroblast growth factor in normal tissues. Lab. Inv. 1990; 63:832-  840.

Haimovitz-Friedman A, Falcone DJ, Vlodavsky I, Schirrmacher V, Eldor A, Fuks Z. Activation of platelet heparitinase by tumor cell derived factors. Blood 1991;78: 789-796.

Haimovitz-Friedman A, Vlodavsky I, Chaudhuri A, Witte L, Fuks Z. Autocrine effects of Fibroblast growth factor (FGF) in repair of radiation damage in endothelial cells. Cancer Research 1991; 51:2552-2558.

Godder K, Vlodavsky I, Eldor A, Weksler BB, Haimovitz-Friedman A, Fuks Z. Heparanase activity in cultured endothelial cells. J.Cell.Physio. 1991; 148: 274-280.

Fuks Z, Vlodavsky I, Andreeff M, McLoughlin M, Haimovitz-Friedman A. Effects of Extracellular Matrix on the response of Endothelial Cells to Radiation in vitro. Eur.J. Cancer 1992; 28/A: 725-731.

Falcone DJ, McCaffey TA, Haimovitz-Friedman A, Vergilio J, Nicholson C. Macrophage and Foam cell release of matrix bound growth factors: Role of Plasminogen activation. J. Biol.Chem. 1993; 268: 11951-11958.

Falcone DJ, McCaffey TA, Haimovitz-Friedman A, Garcia M. Transforming growth factor-b1 stimulates macrophage urokinase expression and release of matrix bound basic fibroblast growth factor. J. Cell. Physiol. 1993; 155:595-605.

Fuks Z, Persaud R, Alfieri A, McLoughlin M, Schwartz J L, Cordon-Cardo C, Seddon AP, Haimovitz-Friedman A. Basic Fibroblast Factor Protects Endothelial Cells Against Radiation-Induced Programmed Cell Death in vitro and in vivo. Cancer Res.1994; 54:2582-2590.

Haimovitz-Friedman A, Balaban N, McLaughlin M, Ehleiter D, Michaeli J, Fuks Z. Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells Against Radiation-Induced Apoptosis. Cancer Res. 1994; 54:2591-2597.

Haimovitz-Friedman A, Kan C-C, Ehleiter D, Persaud R, McLaughlin M, Fuks Z. Ionizing Radiation Acts Directly on Cellular Membranes to Generate Ceramide and Initiate Apoptosis. J. Exp. Med. 1994; 180:525-535.

Haimovitz-Friedman A, Witte L, Chaudhuri A, McLaughlin M, Fuks Z. Induction of growth factor genes in endothelial cells by ionizing radiation. Rad. Onc. Inv. 1995; 3:1-8.

Fuks Z, Alfieri A, Haimovitz-Friedman A, Seddon A P, Cordon-Cardo C. Intravenous basic fibroblast growth factor protects the lung but not the mediastinal organs against radiation-induced apoptosis in vivo. Cancer Journal 1995; 1:62-72.

Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick RN. Ceramide synthase mediates daunorubacin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995; 82:405-414.

Schwartz GK, Haimovitz-Friedman A, Dhupar SK, Ehleiter D, Maslak P, Lai L, Loganzo, Jr. F, Kelsen DP, Fuks Z, Albino AP. Potentiation of apoptosis by treatment with the protein kinase C specific inhibitor Safingol in mitomycin C-treated gastric cancer cells. J. Natl. Can. Inst. 1995; 87:1394-1399.

Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Environmental stresses signal apoptosis through a ceramide-initiated SAPK/JNK-mediated cascade. Nature, 1996; 380:75-79.

Santana P, Peña LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, Cordon-Cardo C, Schuchman EH, Fuks Z, Kolesnick RN. Acid spingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 1996; 86:189-199.

Fenig E, Wieder R, Paglin S, Wang H, Persaud R, Haimovitz-Friedman A, Fuks Z, Yahalom J.  Basic fibroblast growth factor confers growth inhibition and MAP kinase activation in human breast cancer cells. Clinical Cancer Research, 1997; 3:135-142.

Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto M, McLoughlin M, Gallily R, Edwards III CK, Schuchman EH, Fuks Z, Kolesnick RN. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med. 1997; 186:1831-1841.

Garzotto M, White-Jones M, Jiang Y, Ehleiter D, Liao WC, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. 12-O-Tetredecanoylphorbol-13-acetate-induced Apoptosis in LNCaP Cells is Mediated through Ceramide Synthase. Can. Res., 1998, 58:2260-2264.

Suy S, Mitchell JB, Ehleiter D, Haimovitz-Friedman A, Kasid U. Nitroxides tempol and tempo induce divergent signal transduction pathways in MDA-MB 231 breast cancer cells. J. Biol. Chem. 1998; 273: 17871-17878.

Krasilnikov M, Adler V, Fuchs SY. Dong Z, Haimovitz-Friedman A, Herlyn M, Ronai Z.  Contribution of Phosphatidylinositol 3-Kinase to Radiation Resistanse in Human Melanoma Cells. Mol. Carc. 1999; 24:64-69.

Liao W C*, Haimovitz-Friedman A*, Persaud R, McLoughlin M, Ehleiter D, Zhang N, Gatei M, Lavin M, Kolesnick RN, Fuks Z. ATM inhibits DNA damage-induced apoptosis via ceramide synthase. J. Biol. Chem. 1999; 274:17908-17917. *Both authors contributed equally to this publication.

Separovic D, Pink JJ, Oleinick NL, Kester M, Boothman DA, McLoughlin M, Pena LA, Haimovitz-Friedman A. Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis. Biochem Biophys Res Commun. 1999; 258: 506-512.

Garzotto M, Haimovitz-Friedman A, White-Jones M, Liao W-C, Huryk R, Heston DW, Cordon-Cardo C, Kolesnick RN, Fuks Z. Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Can. Res. 1999; 59:5194-520.

Lozano J, Menendez S, Morales A, Liao W-C, Wagman R, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts. J Biol Chem 2000, 276:442-448.

Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed J, Schuchman EH, Kolesnick RN, Tilly JL. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med. 2000 Oct;6(10):1109-1114.

Paris F, Grassme H, Cremesti A, Zager J, Fong Y, Haimovitz-Friedman A, Fuks Z, Gulbins E, Kolesnick RN. Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem 2001, 276:8297-8305.

Paris F, Kang A, Capodieci P, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Fuks Z, Kolesnick RN. Endothelial Apoptosis is the Primary Lesion Initiating Radiation Damage to the Intestines. Science, 2001 July 293:293-297.

Li C-M, Park J-H, Simonaro CM, He X, Gordon RE, Haimovitz-Friedman A, Ehleiter D, Paris F, Manova K, Hepbiloikler S, Fuks Z, Sandhoff K, Kolesnick, R, Schuchman EH. Insertional Mutagenesis of the Mouse Acid Ceramidase Gene Leads to Early Embryonic Lethality in Homozygotes and Progresive Lipid Storage Disease in Heterozygotes. Genomics, 79:218-224, 2002.

Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick RN. Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med. 2002 ; 8:901-902.

Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Tumor response to low-dose radiotherapy regulated by endothelial cell apoptosis. Science 2003; 300:1155-1159.

She Y, Lee F, Chen J, Haimovitz-Friedman A, Miller VA, Rusch VR, Kris MG, Sirotnack FM. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index. Clin Cancer Res., 9: 3773-3778, 2003.

Li Y-Q, Chen P, Haimovitz-Friedman A, Reilly RM, Wong CS. Radiation-induced acute blood-brain barrier disruption is mediated by the acid sphingomyelinase pathway. Cancer Res., 63:5950-5956, 2003.

Maj J, Paris F, Haimovitz-Friedman A, Venkatraman E, Kolesnick R, Fuks, Z. Microvascular function regulates intestinal crypt response to radiation. Can. Res., 2003, 63: 4338-4441.

Jung CP, Motwani MV, Kortmansky J, Haimovitz-Friedman A, Sirotnak FM, She Y, Gonen, M,  Schwartz GK. The cyclin-dependent kinase inhibitor flavopiridol potentiates irradiation-induced apoptosis             in colon and gastric cancer cells. Can. Res., 2003, 9: 6052-6061.

Garcia-Barros M, Lacorazza D, Petrie H, Haimovitz-Friedman A, Cordon-Cardo C, Nimer S, Fuks Z, Kolesnick R. Host acid sphingomyelinase regulates microvascular function not tumor immunity. Can Res., 2004, 64: 8285-8291.

Truman J-P, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem 2005, 280: 23262-23272.

Chang H-J, Maj J, Paris FE, Xing HR, Zhang J, Truman J-P, Cordon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med., 2005, 11: 484-490.

Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, et al. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett 2007; 581(27):5289-94.

Rotolo J, Maj J, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng E, Kolesnick R, Fuks Z. Bax and bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. Int J Radiat Oncol Biol Phys., 2008, 70: 321-650.

Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung J-U, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman J-P, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, and Marquez VE. Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. J Med Chem 2008; 51(17): 5198-220.

Deng X, Yin X, Allan R, Lu D, Haimovitz-Friedman A, Fuks Z, Shaham S, Kolesnick R.  Ceramide Biogenesis is Required for Radiation-induced Apoptosis in the Germ Line of Caenorhabditis elegans. Science 2008: 322,110-115.

Coward J, Ambrosini G, Musi E, Truman JP, Haimovitz-Friedman A, Allegood JC, Wang E, Merrill AH Jr, Schwartz GK. Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the P12-kinase pathway. Authophage 2009 Feb 6; 5(2).

Truman J-P, Rotenberg SA, Kang J-H, Lerman G, Fuks Z, Kolesnick R, Marquez VE, and Haimovitz-Friedman A. PKCa activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer Biol Ther 2009: 8(1): 54-63.

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R. A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem. 2009;24(3-4):219-30.

Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Kinase suppressor of Rastransphosphorylates c-Raf-1. Biochem Biophys Res Commun. 2009;390(3):434-40.

Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res. 2010;70(3):957-67.

Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal. 2010. 22(9):1300-7.

Avraham T, Yan A, Zampell JC, Daluvoy SV, Haimovitz-Friedman A, Cordeiro AP, Mehrara BJ. Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-{beta}1 mediated tissue fibrosis. Am J Physiol Cell Physiol. 2010 Sep;299(3):C589-605.

Truman JP, Garcia-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A. Endothelial Membrane Remodeling is Obligate for Anti-angiogenic Radiosensitization during Tumor Radiosurgery. PLoS ONE 2010 Sept 30;5(8): e12310.

Garcia-Barros M, Thin TH, Cordon-Cardo C, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Impact of Stromal Sensitivity on Radiation Response of Tumors Implanted in SCID Hosts Revisited. Cancer Research 2010 Oct 15;70(20):8179-86.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao W-C, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PLoS ONE 2011. 6(6): e19783.

Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ; NCI Workshop Participants. Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010. Radiat Res. 2011; 176(3):e0016-21.

Rotolo J, Stancevic B, Zhang J, Hua G, Fuller J, Yin X, Haimovitz-Friedman A, Kim K, Qian M, Cardó- Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R. Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest. 2012 May 1;122(5):1786-90.

Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA and Kotula L. Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice. Oncogenesis. 2012; doi:10.1038/oncsis.2012.28. www.nature.com/oncsis

Hua G, Thin TH, Feldman R, Haimovitz–Friedman A, Clevers H, Fuks Z, Kolesnick R. Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology 2012; 143(5):1266-76. doi: 10.1053/j.gastro.2012.07.106.

Stancevic B, Varda-Bloom N, Cheng J, Fuller JD, Rotolo JA, García-Barros M, Feldman R, Rao S, Weichselbaum RR, Harats D, Haimovitz-Friedman A, Fuks Z, Sadelain M, Kolesnick R. Adenoviral Transduction of Human Acid Sphingomyelinase into Neo-angiogenic Endothelium Radiosensitizes Tumor Cure. PLoS ONE 2013 8(8): e6902

Rao SS, Thompson C, Cheng J, Haimovitz-Friedman A, Powell SN, Fuks Z, Kolesnick RN. Axitinib sensitization of high single dose radiotherapy. Radiother Oncol (2014), http://dx.doi.org/10.1016/j.randonc.2014.02.010.

Boppana NB, Kodiha M, Stochaj U, Lin H, Haimovitz-Friedman A, Bielawska A, Bielawski J, Divine GW, Boyd JA, Korbelik M, Separovic D.  Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. Photochem. Photobiol. Sci., 2014, Advance Article DOI: 10.1039/C4PP00292J.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Hubbard EJ, Kolesnick R. Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PLoS One. 2015 Jun 29;10(6):e0127862. doi: 10.1371/journal.pone.0127862. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0141673. PMID: 26120834

Shamay Y, Elkabets M, Li H, Shah J, Brook S, Wang F, Adler K, Baut E, Scaltriti M, Jena PV, Gardner EE, Poirier JT, Rudin CM, Baselga J, Haimovitz-Friedman A, Heller DA. P-selectin is a nanotherapeutic delivery target in the tumor microenvironment. Sci Transl Med. 2016 Jun 29;8(345): 345ra87. doi: 10.1126/scitranslmed.aaf7374. PMID: 27358497

Mizrachi A, Cotrim AP, Katabi N, Mitchel JB, Verheij M, Haimovitz-Friedman A. Radiation-induced microvascular injury as a mechanism of salivary gland hypofunction and potential target for radioprotectors. Radiat Res. 2016 Aug; 186(2):189-95. doi: 10.1667/RR14431.1. PMID: 27459704

Jacobi J, Garcia-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Manova K, Fuks Z, Kolesnick R, Haimovitz-Friedman A. Targeting acid sphingomyelinase with anti-angiogenic chemotherapy. Cell Signal. 2016 Oct 1. pii: S0898-6568(16)30236-4. doi: 10.1016/j.cellsig.2016.09.010. [Epub ahead of print] PMID: 27702691

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN,  Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M. Tumour-specific PI3K inhibition via             nanoparticle-targeted delivery in head and neck squamous cell carcinoma. Nat Commun. 2017 Feb 13;8:14292. doi: 10.1038/ncomms14292. PMID: 28194032.

Hua G, Wang C, Pan Y, Zeng Z, Lee SG, Martin ML, Haimovitz-Friedman A, Fuks Z, Paty PB, Kolesnick R.  Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells. Cancer Res. 2017 Feb 15. doi: 10.1158/0008-5472.CAN-15-2870. [Epub ahead of print] PMID: 28202528.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R. Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation. Cell Signal. 2017 Feb 24; 34:86-91. doi: 10.1016/j.cellsig.2017.02.021. [Epub ahead of print] PMID: 28238856. DOI: 10.1016/j.cellsig.2017.02.021

Russell J, Pillarsetty N, Kramer RM, Romesser PB, Desai P, Haimovitz-Friedman A, Lowery MA, Humm JL. In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2’-deoxy-2’-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. Mol Imaging Biol. 2017 Mar 27. doi: 10.1007/s11307-017-1078-6. [Epub ahead of print] PMID: 28349292.

Hajj C, Russell J, Hart CP, Goodman KA, Lowery MA, Haimovitz-Friedman A, Deasy JO, Humm JL. A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model. Transl Oncol. 2017 Jul 21;10(5):760-765. doi: 10.1016/j.tranon.2017.06.010. [Epub ahead of print] PubMed PMID: 28778024; PubMed Central PMCID: PMC5538966.

Martin ML, Zeng Z, Adileh M, Jacobo A, Li C, Vakiani E, Hua G, Zhang L, Haimovitz-Friedman A, Fuks Z, Kolesnick R. Logarithmic expansion of LGR5+ cells in human colorectal cancer. Cellular signaling. 2018 Jan 1; 42:97-105. doi: 10.1016/j.cellsig.2017.09.018. Epub 2017 Sep 25.

Wang F, Li H, Markovsky E, Glass R, de Stanchina E, Powell SN, Schwartz GK, Haimovitz-Friedman A. Pazopanib radio-sensitization of human sarcoma tumors. Oncotarget. 2018 Feb 6;9(10):9311. doi: 10.18632/oncotarget.24281. eCollection 2018 Feb 6.