Human Oncology & Pathogenesis Program

The Asmin Tulpule Lab


Asmin Tulpule
Asmin Tulpule, MD, PhD

The Tulpule Lab is interested in a long-standing question in cell biology: how do cells organize and compartmentalize critical cellular processes within the crowded and heterogeneous intracellular space? We focus on an emerging set of self-assembling, protein-based structures known as biomolecular condensates and their role in cancer, including a newly discovered pathogenic condensate – membraneless receptor tyrosine kinase (RTK) protein granules. Through interdisciplinary approaches combining cancer signaling, structural biology, biophysics, and high-resolution microscopy, we hope to understand how the compartmentalization of oncogenic fusion proteins can both co-opt and disrupt cellular condensates in order to drive cancer.  

View Lab Overview


Menon S, Breese MR, Lin YP, Allegakoen HP, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Trever G. Bivona#, Asmin Tulpule #. FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. bioRxiv 2023.04.30.538578; doi:

Gonzalez-Martinez D, Roth L, Mumford TR, Guan J, Huang B, Tulpule A, Bivona TG, Bugaj LJ. Oncogenic protein condensates suppress growth factor perception and modulate drug tolerance. Biorxiv. doi:

View All Publications


Asmin Tulpule

Asmin Tulpule, MD, PhD


  • The Tulpule lab studies how cells compartmentalize critical cellular processes with a focus on biomolecular condensates in cancer.
  • MD, Harvard Medical School
  • PhD, Harvard University
[email protected]
Email Address


Alexandra Cote

Research Technician

Rhode Gedeon

Administrative Assistant

Sumit Kumar Dey

Senior Research Scientist

Shruti Menon

Postdoctoral Fellow

Lab Affiliations


  • NCI Career Development Award K08 (2023 – 2028)
  • Hyundai Hope on Wheels Young Investigator Award (2023-2025)
  • St. Baldrick’s Foundation Scholar Award (2018)
  • UCSF Physician-Scientist Scholar Program (2017-2022)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

We are looking for highly motivated graduate students, postdoctoral fellows, and clinical fellows with laboratory experience.

Apply now

Get in Touch