The Babak Mehrara Lab: Publications

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Visit PubMed for a full listing of Babak J. Mehrara’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse J, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E. (2019). Stem cell-driven lymphatic remodeling coordinates tissue regeneration. Science. 2019 Dec 6;366(6470):1218-1225.

Kataru RP, Ly CL, Shin J, Park HJ, Baik JE, Rehal S, Ortega S, Lyden D, Mehrara BJ. (2019). Tumor Lymphatic Function Regulates Tumor Inflammatory and Immunosuppressive Microenvironments. Cancer Immunol Res. 2019 Aug;7(8):1345-1358.

Kataru RP, Wiser I, Baik JE, Park HJ, Rehal S, Shin JY, Mehrara BJ. (2019). Fibrosis and secondary lymphedema: chicken or egg?. Transl Res. 2019 Jul;209:68-76.

Kataru RP, Baik JE, Park HJ, Wiser I, Rehal S, Shin JY, Mehrara BJ. (2019). Regulation of Immune Function by the Lymphatic System in Lymphedema. Front Immunol. 2019 Mar 18;10:470.

Ly CL, Nores GDG, Kataru RP, Mehrara BJ. (2019). T helper 2 differentiation is necessary for development of lymphedema. Transl Res. 2019 Apr;206:57-70.

Ly CL, Cuzzone DA, Kataru RP, Mehrara BJ. (2019). Small Numbers of CD4+ T Cells Can Induce Development of Lymphedema. Plast Reconstr Surg. 2019 Mar;143(3):518e-526e.

Hespe GE, Ly CL, Kataru RP, Mehrara BJ. (2019). Baseline Lymphatic Dysfunction Amplifies the Negative Effects of Lymphatic Injury. Plast Reconstr Surg. 2019 Jan;143(1):77e-87e.

Garcia Nores GD, Ly CL, Cuzzone DA, Kataru RP, Hespe GE, Torrisi JS, Huang JJ, Gardenier JC, Savetsky IL, Nitti MD, Yu JZ, Rehal S, Mehrara BJ. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema. Nat Commun. 2018 May 17;9(1):1970.

Garcia Nores GD, Ly CL, Savetsky IL, Kataru RP, Ghanta S, Hespe GE, Rockson SG, Mehrara BJ. regulatory T cells Mediate Local Immunosuppression in Lymphedema. J Invest Dematol. 2018 Feb;138(2):325-335.

Dayan JH, Ly CL, Kataru RP, Mehrara BJ. Lymphedema: Pathogenesis and Novel Therapies. Annu Rev Med. 2018 Jan 29;69:263-276.

Gardenier JC, Kataru RP, Hespe GE, Savetsky IL, Torrisi JS, Nores GD, Jowhar DK, Nitti MD, Schofield RC, Carlow DC, Mehrara BJ. Topical tacrolimus for the treatment of secondary lymphedema. Nat Commun. 2017 Feb 10;8:14345.

Ly CL, Kataru RP, Mehrara BJ. Inflammatory manifestations of Lymphedema. Int J Mol Sci. 2017 Jan 17;18(1).

Huang JJ, Gardenier JC, Hespe GE, Garcia Nores GD, Kataru RP, Ly CL, Martinez-Corral I, Ortega S, Mehrara BJ. Lymph Node Transplantation Decreases Swelling and Restores Immune Responses in a Transgenic Model of Lymphedema. PLos One. 2016 Dec. 12;11(12).

Gardenier JC, Hespe GE, Kataru RP, Savetsky IL, Torrisi JS, Nores GD, Dayan JJ, Chang D, Zampell J, Martinez-Corral I, Ortega S, Mehrara BJ. Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema. JCI Insight. 2016 Sep 22;1(15).

Nitti MD, Hespe GE, Kataru RP, Garcia Nores GD, Savetsky IL, Torrisi JS, Gardenier JC, Dannenberg AJ, Mehrara BJ. Obesity-induced lymphatic dysfunction is reversible with weight loss. Journal of Physiology. 2016 Dec 1;594(23):7073-7087.

Torrisi JS, Hespe GE, Cuzzone DA, Savetsky IL, Nitti MD, Gardenier JC, Garcia Nores GD, Jowhar D, Kataru RP, Mehrara BJ. Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity. Scientific reports. 2016;6:19817. Epub 2016/01/23. doi: 10.1038/srep19817. PubMed Central PMCID: PMCPmc4726274.

Hespe GE, Kataru RP, Savetsky IL, Garcia Nores GD, Torrisi JS, Nitti MD, Gardenier JC, Zhou J, Yu JZ, Jones LW, Mehrara BJ. Exercise training improves obesity-related lymphatic dysfunction. The Journal of physiology. 2016. Epub 2016/03/05. doi: 10.1113/jp271757. PubMed

Garcia Nores GD, Cuzzone DA, Albano NJ, Hespe GE, Kataru RP, Torrisi JS, Gardenier JC, Savetsky IL, Aschen SZ, Nitti MD, Mehrara BJ. Obesity but not high-fat diet impairs lymphatic function. International journal of obesity (2005). 2016. Epub 2016/05/21. doi: 10.1038/ijo.2016.96.

Savetsky IL, Ghanta S, Gardenier JC, Torrisi JS, Garcia Nores GD, Hespe GE, Nitti MD, Kataru RP, Mehrara BJ. Th2 cytokines inhibit lymphangiogenesis. PloS one. 2015;10(6):e0126908. Epub 2015/06/04. doi: 10.1371/journal.pone.0126908. PubMed Central PMCID: PMCPmc4454507.

Savetsky IL, Albano NJ, Cuzzone DA, Gardenier JC, Torrisi JS, Garcia Nores GD, Nitti MD, Hespe GE, Nelson TS, Kataru RP, Dixon JB, Mehrara BJ. Lymphatic Function Regulates Contact Hypersensitivity Dermatitis in Obesity. The Journal of investigative dermatology. 2015;135(11):2742-52. Epub 2015/07/16. doi: 10.1038/jid.2015.283. PubMed Central PMCID: PMCPmc4641050.

Ghanta S, Cuzzone DA, Torrisi JS, Albano NJ, Joseph WJ, Savetsky IL, Gardenier JC, Chang D, Zampell JC, Mehrara BJ. Regulation of inflammation and fibrosis by macrophages in lymphedema. American journal of physiology Heart and circulatory physiology. 2015;308(9):H1065-77. Epub 2015/03/01. doi: 10.1152/ajpheart.00598.2014. PubMed Central PMCID: PMCPmc4551121.

Cuzzone DA, Albano NJ, Aschen SZ, Ghanta S, Mehrara BJ. Decellularized Lymph Nodes as Scaffolds for Tissue Engineered Lymph Nodes. Lymphatic research and biology. 2015;13(3):186-94. Epub 2014/08/22. doi: 10.1089/lrb.2013.0054. PubMed Central PMCID: PMCPmc4575505.

Savetsky IL, Torrisi JS, Cuzzone DA, Ghanta S, Albano NJ, Gardenier JC, Joseph WJ, Mehrara BJ. Obesity increases inflammation and impairs lymphatic function in a mouse model of lymphedema. American journal of physiology Heart and circulatory physiology. 2014;307(2):H165-72. Epub 2014/05/27. doi: 10.1152/ajpheart.00244.2014. PubMed Central PMCID: PMCPmc4101643.

Mehrara BJ, Greene AK. Lymphedema and obesity: is there a link? Plastic and reconstructive surgery. 2014;134(1):154e-60e. Epub 2014/07/17. doi: 10.1097/prs.0000000000000268. PubMed Central PMCID: PMCPmc4393748.

Joseph WJ, Aschen S, Ghanta S, Cuzzone D, Albano N, Gardenier J, Savetsky I, Torrisi J, Mehrara BJ. Sterile inflammation after lymph node transfer improves lymphatic function and regeneration. Plastic and reconstructive surgery. 2014;134(1):60-8. Epub 2014/07/17. doi: 10.1097/prs.0000000000000286. PubMed Central PMCID: PMCPmc4101920.

Cuzzone DA, Weitman ES, Albano NJ, Ghanta S, Savetsky IL, Gardenier JC, Joseph WJ, Torrisi JS, Bromberg JF, Olszewski WL, Rockson SG, Mehrara BJ. IL-6 regulates adipose deposition and homeostasis in lymphedema. American journal of physiology Heart and circulatory physiology. 2014;306(10):H1426-34. Epub 2014/03/19. doi: 10.1152/ajpheart.01019.2013. PubMed Central PMCID: PMCPmc4024716.

Weitman ES, Aschen SZ, Farias-Eisner G, Albano N, Cuzzone DA, Ghanta S, Zampell JC, Thorek D, Mehrara BJ. Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes. PloS one. 2013;8(8):e70703. Epub 2013/08/21. doi: 10.1371/journal.pone.0070703. PubMed Central PMCID: PMCPmc3741281.

Weitman E, Cuzzone D, Mehrara BJ. Tissue engineering and regeneration of lymphatic structures. Future oncology (London, England). 2013;9(9):1365-74. Epub 2013/08/29. doi: 10.2217/fon.13.110. PubMed Central PMCID: PMCPmc4095806.

Avraham T, Zampell JC, Yan A, Elhadad S, Weitman ES, Rockson SG, Bromberg J, Mehrara BJ. Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013;27(3):1114-26. Epub 2012/11/30. doi: 10.1096/fj.12-222695. PubMed Central PMCID: PMCPmc3574290.

Zampell JC, Yan A, Elhadad S, Avraham T, Weitman E, Mehrara BJ. CD4(+) cells regulate fibrosis and lymphangiogenesis in response to lymphatic fluid stasis. PloS one. 2012;7(11):e49940. Epub 2012/11/28. doi: 10.1371/journal.pone.0049940. PubMed Central PMCID: PMCPmc3502174.

Zampell JC, Yan A, Avraham T, Daluvoy S, Weitman ES, Mehrara BJ. HIF-1alpha coordinates lymphangiogenesis during wound healing and in response to inflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012;26(3):1027-39. Epub 2011/11/10. doi: 10.1096/fj.11-195321. PubMed Central PMCID: PMCPmc3470728.

Zampell JC, Elhadad S, Avraham T, Weitman E, Aschen S, Yan A, Mehrara BJ. Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injury. American journal of physiology Cell physiology. 2012;302(4):C709-19. Epub 2011/11/04. doi: 10.1152/ajpcell.00284.2011. PubMed Central PMCID: PMCPmc3287358.

Zampell JC, Avraham T, Yoder N, Fort N, Yan A, Weitman ES, Mehrara BJ. Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines. American journal of physiology Cell physiology. 2012;302(2):C392-404. Epub 2011/09/24. doi: 10.1152/ajpcell.00306.2011. PubMed Central PMCID: PMCPmc3328842.

Zampell JC, Aschen S, Weitman ES, Yan A, Elhadad S, De Brot M, Mehrara BJ. Regulation of adipogenesis by lymphatic fluid stasis: part I. Adipogenesis, fibrosis, and inflammation. Plastic and reconstructive surgery. 2012;129(4):825-34. Epub 2012/03/30. doi: 10.1097/PRS.0b013e3182450b2d. PubMed Central PMCID: PMCPmc3433726.

Aschen S, Zampell JC, Elhadad S, Weitman E, De Brot M, Mehrara BJ. Regulation of adipogenesis by lymphatic fluid stasis: part II. Expression of adipose differentiation genes. Plastic and reconstructive surgery. 2012;129(4):838-47. Epub 2012/03/30. doi: 10.1097/PRS.0b013e3182450b47. PubMed Central PMCID: PMCPmc3445411.

Yan A, Avraham T, Zampell JC, Haviv YS, Weitman E, Mehrara BJ. Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-beta1 inhibition. Future oncology (London, England). 2011;7(12):1457-73. Epub 2011/11/25. doi: 10.2217/fon.11.121. PubMed Central PMCID: PMCPmc3263831.

Yan A, Avraham T, Zampell JC, Aschen SZ, Mehrara BJ. Mechanisms of lymphatic regeneration after tissue transfer. PloS one. 2011;6(2):e17201. Epub 2011/03/02. doi: 10.1371/journal.pone.0017201. PubMed Central PMCID: PMCPmc3040774.

Avraham T, Daluvoy S, Zampell J, Yan A, Haviv YS, Rockson SG, Mehrara BJ. Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair. The American journal of pathology. 2010;177(6):3202-14. Epub 2010/11/09. doi: 10.2353/ajpath.2010.100594. PubMed Central PMCID: PMCPmc2993295.

Avraham T, Clavin NW, Daluvoy SV, Fernandez J, Soares MA, Cordeiro AP, Mehrara BJ. Fibrosis is a key inhibitor of lymphatic regeneration. Plastic and reconstructive surgery. 2009;124(2):438-50. Epub 2009/08/01. doi: 10.1097/PRS.0b013e3181adcf4b.

Clavin NW, Avraham T, Fernandez J, Daluvoy SV, Soares MA, Chaudhry A, Mehrara BJ. TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair. American journal of physiology Heart and circulatory physiology. 2008;295(5):H2113-27. Epub 2008/10/14. doi: 10.1152/ajpheart.00879.2008.