Human Oncology & Pathogenesis Program

The Christine Iacobuzio-Donahue Lab

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Research

Christine Iacobuzio-Donahue
Christine A. Iacobuzio-Donahue, MD, PhD
David M. Rubenstein Center Chair for Pancreatic Cancer Research; Director, Center for Pancreatic Cancer Research

Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.

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The Christine Iacobuzio-Donahue Lab

Featured News

Q&A
MSK pathologist Christine Iacobuzio-Donahue
What Evolution Can Tell Us about How Cancer Spreads

Meet Christine Iacobuzio-Donahue, a physician-scientist who studies cancer metastasis and is collaborating on genetics research with scientists at the American Museum of Natural History.
Finding
A pancreatic cancer cell
Two Studies Shed Light on Genetics of Metastatic Pancreatic Cancer

New research of metastatic pancreatic cancer has shown that the same mutations are involved in driving both the primary tumor and the metastases.

Publications

Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics. Kim MS, Zhong Y, Yachida S, Rajeshkumar NV, Abel ML, Marimuthu A, Mudgal K, Hruban RH, Poling JS, Tyner JW, Maitra A, Iacobuzio-Donahue CA*, Pandey A. Mol Cell Proteomics. 2014 Jun 3. pii: mcp.M114.038547. *co-senior author

Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, Iacobuzio-Donahue CA. Clin Cancer Res. 2012 Nov 15;18(22):6339-47.

Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Haeno H, Gonen M, Davis MB, Herman JM, Iacobuzio-Donahue CA*, Michor F. Cell. 2012 Jan 20;148(1-2):362-75. *co-senior author

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Nature. 2010 Oct 28;467(7319):1114-7.

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D. J Clin Oncol. 2009 Apr 10;27(11):1806-13.

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People

Christine Iacobuzio-Donahue

Christine A. Iacobuzio-Donahue, MD, PhD

David M. Rubenstein Center Chair for Pancreatic Cancer Research; Director, Center for Pancreatic Cancer Research

  • Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.
  • MD, PhD, Boston University
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Physician profile

Members

Alexandra Miller
Alexandra Miller

Assistant Attending

Priscilla Baez
Priscilla Baez

Research Project Associate

Jungeui Hong
Jungeui Hong
Jinlong Huang
Jinlong Huang

Research Fellow

Rajya Kappagantula
Rajya Kappagantula

Research Technician

Elias-Ramzey Karnoub
Elias-Ramzey Karnoub
Alicia Maisonet
Alicia Maisonet

Program Assistant

Alvin Makohon-Moore
Alvin Makohon-Moore

Research Associate

Helen Martirosova
Helen Martirosova

Graduate Research Assistant

Jerry Melchor
Jerry Melchor

Lab Manager

Katelyn Mullen
Katelyn Mullen

Graduate Student

Hope Narozniak
Hope Narozniak

Research Technician

Wungki Park
Wungki Park

Assistant Attending

Derwin Pena
Derwin Pena

Morgue Attendant

Shigeaki Umeda
Shigeaki Umeda

Research Associate

Haochen Zhang
Haochen Zhang
Yi Zhong
Yi Zhong

Research Associate

Amanda Zucker
Amanda Zucker

Research Technician

Lab Alumni
Marc Attiyeh
Marc Attiyeh

Research Fellow

Jun Fan
Jun Fan

Research Associate

Akimasa Hayashi
Akimasa Hayashi

Visiting Investigator

Zachary Kohutek
Zachary Kohutek

Assistant Attending Radiation Oncologist

Breanna McMahon
Breanna McMahon

Research Technician

Chelsea Michael
Chelsea Michael

Clinical Coordinator

Salvador Suarez Naranjo
Salvador Suarez Naranjo

Research Associate

Hitomi Sakamoto
Hitomi Sakamoto

Research Fellow

Efsevia Vakiani, MD, PhD
Efsevia Vakiani

Assistant Attending Pathologist

Liguo Zhang
Liguo Zhang

Senior Research Technician

Lab Affiliations

Achievements

  • Team Science Award, American Association for Cancer Research (2012)
  • Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)
  • AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)
  • Member, Alpha Omega Alpha (2002)
  • American Society of Clinical Investigators (2015)
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  • Elected to American Association of University Pathologists (Pluto Society)

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Christine A. Iacobuzio-Donahue discloses the following relationships and financial interests:

  • Bristol-Myers Squibb
    Provision of Services (uncompensated)

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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