The Christine Iacobuzio-Donahue Lab

Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.

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Pictured: Christine Iacobuzio-Donahue

Christine A. Iacobuzio-Donahue, MD, PhD

Associate Director for Translational Research, David M. Rubenstein Center for Pancreatic Cancer Research

Research Focus

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

Lab Members

Career Opportunities

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