Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.
Christine A. Iacobuzio-Donahue, MD, PhD
Director of Genomics Research, David M. Rubenstein Center for Pancreatic Cancer Research
Professor
Research Focus
Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.Education
MD, PhD, Boston UniversityLab Members
Research Fellow
Research Study Assistant II
Research Associate
Visiting Investigator
Research Fellow
Research Technician
Assistant Attending Radiation Oncologist
Administrative Assistant
Lab Manager
Morgue Attendant
Research Fellow
Assistant Attending Pathologist
Senior Research Technician
Research Associate
- Heterogeneity of pancreatic cancer metastases in a single patient revealed by quantitative proteomics. Kim MS, Zhong Y, Yachida S, Rajeshkumar NV, Abel ML, Marimuthu A, Mudgal K, Hruban RH, Poling JS, Tyner JW, Maitra A, Iacobuzio-Donahue CA*, Pandey A. Mol Cell Proteomics. 2014 Jun 3. pii: mcp.M114.038547. *co-senior author
- Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, Hruban RH, Klein AP, Jones S, Velculescu V, Wolfgang CL, Iacobuzio-Donahue CA. Clin Cancer Res. 2012 Nov 15;18(22):6339-47.
- Team Science Award, American Association for Cancer Research (2012)
- Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)
- AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)
- Member, Alpha Omega Alpha (2002)
- American Society of Clinical Investigators (2015)
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- Elected to American Association of University Pathologists (Pluto Society)
