The Christine Iacobuzio-Donahue Lab

Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.

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Pictured: Christine Iacobuzio-Donahue

Christine A. Iacobuzio-Donahue, MD, PhD

Director of Genomics Research, David M. Rubenstein Center for Pancreatic Cancer Research

Research Focus

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

Selected Achievements

  • Team Science Award, American Association for Cancer Research (2012)
  • Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)
  • AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)
  • Member, Alpha Omega Alpha (2002)
  • American Society of Clinical Investigators (2015)
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  • Elected to American Association of University Pathologists (Pluto Society)