Human Oncology & Pathogenesis Program
The Christine Iacobuzio-Donahue Lab
Research

Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.

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Christine A. Iacobuzio-Donahue, MD, PhD
David M. Rubenstein Center Chair for Pancreatic Cancer Research; Director, Center for Pancreatic Cancer Research
- Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.
- MD, PhD, Boston University
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Members







- BS, University of Massachusetts Amherst


Research Project Associate


Research Fellow

Research Technician

Special Fellow

Program Assistant

Research Associate

Graduate Research Assistant

Lab Manager

Assistant Attending

Graduate Student

Morgue Attendant
Research Associate

Research Associate

Research Technician



Lab Alumni

Research Fellow

Research Associate

Visiting Investigator


Assistant Attending Radiation Oncologist

Research Technician

Clinical Coordinator

Research Associate

Research Fellow

Assistant Attending Pathologist

Senior Research Technician
Lab Affilations
Achievements
- Team Science Award, American Association for Cancer Research (2012)
- Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)
- AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)
- Member, Alpha Omega Alpha (2002)
- American Society of Clinical Investigators (2015)
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- Elected to American Association of University Pathologists (Pluto Society)