Human Oncology & Pathogenesis Program
The Kojo Elenitoba-Johnson and Megan Lim Lab
Kojo S. Elenitoba-Johnson is the Chair of the Department of Pathology and Laboratory Medicine and a physician-scientist. Dr. Elenitoba-Johnson’s research focuses on the role of genomic and proteomic alterations in the pathogenesis of lymphomas.
Dr. Megan S. Lim is the Director of the Lymphoma Translational Research Program and Director of the Biofluid Biobank. Dr. Lim is a hematopathologist-scientist who studies the role of genomic and proteomic alterations in the pathogenesis of lymphoma.
The research interests of the Elenitoba-Johnson-Lim lab encompass genomic and functional proteomic approaches to discover novel mechanisms of lymphoma pathogenesis; development of conditional murine models for investigating the role of oncogenes and tumor suppressor genes in lymphocyte development and lymphomas genesis and translational research utilizing innovative genomic and mass spectrometry-based approaches focused on identification of novel genomic and proteomic targets for diagnostic and therapeutic applications.
Sande CM, Wu R, Yang G, Sussman RT, Bigdeli A, Rushton C, Chitturi A, Patel J, Szankasi P, Morrissette JJD, Lim MS, Elenitoba-Johnson KSJ. Rapid and Automated Semiconductor-Based Next-Generation Sequencing for Simultaneous Detection of Somatic DNA and RNA Aberrations in Myeloid Neoplasms. J Mol Diagn. 2022 Dec 8:S1525-1578(22)00342-7. doi: 10.1016/j.jmoldx.2022.11.005. Online ahead of print.
Rolland DCM, Basrur V, Jeon YK, McNeil-Schwalm C, Fermin D, Conlon KP, Zhou Y, Ng SY, Tsou C-C, Brown NA, Thomas DG,. Bailey NG, Omenn GS, Nesvizhskii AI, Weinstock DM, Faryabi RB, Lim MS, and Elenitoba-Johnson KSJ. Functional proteogenomics reveals biomarkers and therapeutic targets in lymphoid cancer. Proc Natl Acad Sci USA. 2017; Jun 20:114(25):6581-86. doi: 10.1073/pnas. Epub 2017 Jun 12.
Kiel M, Sahasrabuddhe A, Rolland D, Velusamy T, Chung F, Schaller M, Bailey N, Betz B, Miranda R, Porcu P, Byrd, JL, Medeiros J, Kunkel S, Bahler D, Lim MS, and Elenitoba-Johnson KSJ. Genomic analyses reveal recurrent mutations in epigenetic modifiers and JAK-STAT pathway in Sézary Syndrome. Nature Communications 2015; Sep 29;6:8470. PMCID: PMC4598843.
Brown NA, Furtado LV, Betz BL, Kiel MJ, Weigelin HC, Lim MS, Elenitoba-Johnson KS. High prevalence of somatic MAP2K1mutations in BRAF V600E-negative Langerhans cell histiocytosis. Blood 2014; Sep 4;124(10):1655-8.
Kiel MJ, Velusamy T, Betz BL, Zhao L, Weigelin HG, Chiang MY, Huebner-Chan DR, Bailey NG, Yang DT, Bhagat G, Miranda RN, Bahler DW, Medeiros LJ, Lim MS, Elenitoba-Johnson KSJ. Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. J Exp Med 2012; 209:1553-65. PMCID: 3428949
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