Hospital Research Teams
The Liang Deng Lab
Research
![Liang Deng, MD, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12530/person/deng_liang_180511_11_1200x800.jpg?h=10d202d3)
Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma.
Research Projects
![Figure 1](https://www.mskcc.org/sites/default/files/node/12530/images/figure1.jpg)
![The Liang Deng Lab](https://www.mskcc.org/sites/default/files/node/12530/main_image/deng-lab_200212_03-1200x800.jpg)
Featured News
![Pictured: Liang Deng](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/19564/image/deng-120116-54-crop.jpg)
![](https://www.mskcc.org/sites/default/files/styles/width_200/public/node/19381/3x2/130319-mary-goll-083.jpg)
Publications Highlights
Yang, N., Wang, Y., Dai, P., Li, T., Zierhut, C., Tan, A., Zhang, Z., Pan, H., Li, Z., Ordureau, A., Xiang, J.Z., Hendrickson, R.C., Funabiki H., Chen, Z., Deng, L. (2023) Vaccinia E5 is a major inhibitor of the DNA sensor cGAS. Nat Commun, 14(1):2898. doi: 10.1038/s41467-023-38514-5 (PMC10201048).
Yang, N., #, Wang, Y.,#, Liu, S., Tariq, S.B., Luna, J. M., Mazo G., Tan, A., Zhang, T., Wang, J., Yan, W., Choi, J., Rossi, A., Xiang, J.Z., Rice, C. M., Merghoub, T., Wolchok, J. D., and Deng, L. (2023) OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. Journal Experimental Medicine 220(8):e20221166. Epub 2023 May 5. PMID: 37145142.
Gu, L., Lin, E., Liu, S., Yang, N., Kurtansky, N., Neumann, N., Stoll, J., Lezcano, C., Pulitzer, M., Noor, S., Markova, A., Rossi, A., Dickson, M., and Deng L. (2023) Efficacy of Immunotherapy with Combination of Cryotherapy and Topical Imiquimod for Treatment of Kaposi Sarcoma. Journal of Medical Virology, 95(1):e28396. PMID: 36504005.
Yang, N., Garcia, A., Meyer, Tuschl T., Merghoub, T., Wolchok, J.D., and L. Deng (2022) Heat-inactivated modified vaccinia virus Ankara boosts Th1 cellular and humoral immunity as a vaccine adjuvant. npj Vaccines (2022) 7(1):120. PMID: 36261460. https://doi.org/10.1038/s41541-022-00542-5.
Yang, N., Luna J.M., Dai, P., Wang, Y., Rice, C.M., and L. Deng. (2022). Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection. Nature Communications 13(1):1671. PMID: 35351885. PMCID: PMC896475.
People
![Liang Deng, MD, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12530/person/deng_liang_180511_11_1200x800.jpg?h=10d202d3)
Liang Deng, MD, PhD
- Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
- [email protected]
- Email Address
- 646-888-6011
- Office Phone
- View physician profile
- Physician profile
Members
![Liang Deng, MD, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12537/3x2/deng_liang_180511_11_1200x800.jpg)
![Ning Yang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158536/main_image/yang-ning_200212_07-1200x800_0.jpg)
![Liang Deng, MD, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12537/3x2/deng_liang_180511_11_1200x800.jpg)
Lab Head
Research Technician
Research Technician
Research Technician
![Ning Yang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158536/main_image/yang-ning_200212_07-1200x800_0.jpg)
Senior Research Scientist
![Peihong Dai](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12536/3x2/dai_180511_08_1200x800.jpg?h=10d202d3)
![Weiyi Wang, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12534/3x2/wang_weiyi_180511_06_1200x800.jpg?h=10d202d3)
![Shuaitong Liu](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/190066/main_image/liu-shuaitong_200212_14-1200x800.jpg?h=10d202d3)
![Gregory Mazo](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158152/3x2/mazo_180511_08_1200x800.jpg?h=10d202d3)
![Yi Wang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158155/3x2/wang_yi_180511_08_1200x800.jpg?h=10d202d3)
Lab Alumni
![Peihong Dai](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12536/3x2/dai_180511_08_1200x800.jpg?h=10d202d3)
Research Assistant
![Weiyi Wang, PhD](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/12534/3x2/wang_weiyi_180511_06_1200x800.jpg?h=10d202d3)
Senior Research Scientist
Visiting Scholar
![Shuaitong Liu](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/190066/main_image/liu-shuaitong_200212_14-1200x800.jpg?h=10d202d3)
Research Technician
![Gregory Mazo](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158152/3x2/mazo_180511_08_1200x800.jpg?h=10d202d3)
Research Fellow
Research Fellow
Medical Student Research Fellow
![Yi Wang](https://www.mskcc.org/sites/default/files/styles/width_200_1x1/public/node/158155/3x2/wang_yi_180511_08_1200x800.jpg?h=10d202d3)
Research Assistant
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
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Office Phone
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Office Fax
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Liang Deng discloses the following relationships and financial interests:
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Immunogenesis, Inc.
Intellectual Property Rights
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Imvaq Therapeutics
Equity; Intellectual Property Rights; Professional Services and Activities (Uncompensated)
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].