Memorial Hospital Research Laboratories
The Liang Deng Lab
Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma.
Yang, N., J.M. Luna, P. Dai, Y. Wang, C.M. Rice, and L. Deng (2020) Lung type II epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs. BioRxiv 10.1101/2020.01.20.910927.
Shaw K.S., G.H. Nguyen, M. Lacouture, and L. Deng. (2017). Combination of imiquimod with cryotherapy for the treatment of penile intraepithelial neoplasia. JAAD Case Rep. 3(6):546-549.
Dai, P., W. Wang, N. Yang, C. Serna-Tamayo, J.M. Ricca, D. Zamarin, S. Shuman, T. Merghoub, J.D. Wolchok, and L. Deng. (2017). Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent DCs. Science Immunology 2, eaal1713: 1-15.
Gao, P., T. Zillinger, W. Wang, M. Ascano, P. dai, G. Hartmann, T. Tuschl, L Deng, W. Barchet, and D.J. Patel. (2014). Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. Cell Rep 8:1-9.
Dai, P., W. Wang, H. Cao, F. Avogadri, L. Dai, I. Drexler, J. A. Joyce, T. Merghoub, S. Shuman, and L. Deng. Modified vaccinia virus Ankara triggers type I IFN production in conventional dendritic cells via a cGAS/STING-dependent cytosolic DNA-sensing pathway. PLoS Pathogens 2014;10:e1003989.
Liang Deng, MD, PhD
- Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Liang Deng discloses the following relationships and financial interests:
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