Brian H. Santich, BA

Graduate Student

Email

santichb@sloankettering.edu

Mentor

Nai-Kong V. Cheung and Morgan Huse

Start Year

2013

Education

BA, University of California, Berkeley

In science, everything can be interesting. Even the most minor differences can lead to amazing discoveries if you can ask the right questions. Additionally, no one is ever an expert. Every field changes constantly, and in order to succeed, one must keep an open mind and foster collaborations. Memorial Sloan Kettering has world-famous research (and researchers), both in the field of cancer and outside of it. Given my interests in immunotherapies, MSK was a clear choice. I felt Gerstner Sloan Kettering was a step above the rest, however, due to its course model: primary literature instead of textbooks, experts teaching the subjects they work in every day, and all of it finishing up within the first year.

Fellowships

Grayer Fellowship (2015-2016)

Publications

Santich BH, Liu H, Liu C, Cheung NK. (2015) Generation of TCR-Like Antibodies Using Phage Display. Methods Mol Biol., 1348, 191-204.

Montezuma-Rusca JM, Moir S, Kardava L, Buckner CM, Louie A, Kim LJ, Santich BH, Wang W, Fankuchen OR, Diaz G, Daub JR, Rosenzweig SD, Chun TW, Li Y, Braylan RC, Calvo KR, Fauci AS. (2015) Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals. J Immunol., 194, 2561-8. PMCID: PMC4355319.

Kohli A, Funk E, Burbelo P, Barrett L, Meissner EG, Santich B, Shaffer A, Johl J, Sidharthan S, Moir S, Kottilil S, Fauci AS. (2015)  Persistently elevated abnormal B-cell subpopulations and anti-core antibodies in patients co-infected with HIV/HCV who relapse. J Med Virol.,  87, 544-52.

Cubas R, van Grevenynghe J, Wills S, Kardava L, Santich BH, Buckner CM, Muir R, Tardif V, Nichols C, Procopio F, He Z, Metcalf T, Ghneim K, Locci M, Ancuta P, Routy JP, Trautmann L, Li Y, McDermott AB, Koup RA, Petrovas C, Migueles SA, Connors M, Tomaras GD, Moir S, Crotty S, Haddad EK. (2015)  Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection. J Immunol., 195, 5625-36. PMCID: PMC4670798.

Kardava L, Moir S, Shah N, Wang W, Wilson R, Buckner CM, Santich BH, Kim LJ, Spurlin EE, Nelson AK, Wheatley AK, Harvey CJ, McDermott AB, Wucherpfennig KW, Chun TW, Tsang JS, Li Y, Fauci AS. (2014)  Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. J Clin Invest., 124, 3252-62. PMCID: PMC4071400.

Sheikh V1, Dersimonian R, Richterman AG, Porter BO, Natarajan V, Burbelo PD, Rupert A, Santich BH, Kardava L, Mican JM, Moir S, Sereti I. (2014) Graves’ disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4(+) T-cell recovery. AIDS, 28, 31-9.

Buckner CM, Moir S, Kardava L, Ho J, Santich BH, Kim LJ, Funk EK, Nelson AK, Winckler B, Chairez CL, Theobald-Whiting NL, Anaya-O’Brien S, Alimchandani M, Quezado MM, Yao MD, Kovacs JA, Chun TW, Fauci AS, Malech HL, De Ravin SS. (2014) CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation. J Allergy Clin Immunol., 133, 1676-85.e5. PMCID: PMC4040303.

Zompi S, Santich BH, Beatty PR, Harris E. (2012) Protection from secondary dengue virus infection in a mouse model reveals the role of serotype cross-reactive B and T cells. J Immunol., 188, 404-16. PMCID: PMC3244532.

Zhou Q, Lee GS, Brady J, Datta S, Katan M, Sheikh A, Martins MS, Bunney TD, Santich BH, Moir S, Kuhns DB, Long Priel DA, Ombrello A, Stone D, Ombrello MJ, Khan J, Milner JD, Kastner DL, Aksentijevich I. (2012)  A hypermorphic missense mutation in PLCG2, encoding phospholipase C?2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Hum Genet., 91, 713-20. PMCID: PMC3484656.

Moir S, De Ravin SS, Santich BH, Kim JY, Posada JG, Ho J, Buckner CM, Wang W, Kardava L, Garofalo M, Marciano BE, Manischewitz J, King LR, Khurana S, Chun TW, Golding H, Fauci AS, Malech HL. (2012) Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells. Blood, 120, 4850-8. PMCID: PMC3520621.