Sonya Li, PhD

Senior Staff Scientist
Sonya Li

My research project has been focused on the technical development of a targeted next-generation sequencing panel to evaluate clonal hematopoiesis (CH) mutations in rare cellular populations and in patients with solid tumor malignancies. Using this panel, we will also study the response to checkpoint blockade in patients harboring CH variants and determine the mechanism of progression from CH to cardiovascular or oncologic disease.

Publications

Wood D, Jones S, Niknafs N, Karchin R, Sausen M, Parpart-Li S, Anagnostou V, Georgiadis A, Papp E, Riley DR, White J, Van Emburgh B, Mitchell J, McCord C, Loverso P, Diaz LA Jr, Angiuoli S, Velculescu VE. A machine learning approach for somatic mutation discovery. Science Translational Medicine. 2018; 10(457).

Parpart-Li S, Bartlett B, Popoli M, Adleff V, Tucker L, Steinberg R, Phallen J, Brahmer J, Azad N, Browner I, Laheru DA, Velculescu VE, Sausen M and Diaz LA Jr. The effect of preservative and temperature on the analysis of circulating tumor DNA. Clin Canc Res. 2017; 23(10):2471-2477.

Jones S, Anagnostou V, Lytle K, Parpart-Li S, Nesselbush M, Riley DR, Shukla M, Chesnick B, Kadan M, Papp E, Galens KG, Murphy D, Zhang T, Kann L, Sausen M, Angiuoli SV, Diaz LA Jr, Velculescu VE. Personalized genomic analyses for cancer mutation discovery and interpretation. Science Translational Medicine. 2015; 7(283).

Sausen M, Parpart S, Diaz, LA Jr. Circulating Tumor DNA Move Further into the Spotlight. Genomic Medicine. 2014;6(5)35.