Our research focuses on the identification of novel cancer-susceptibility genes using genomic technologies. We are specifically interested in helping to determine the genetic basis of “sporadic” cancers in young adults and children. By comparing germline genomes of cancer case-parent trios, the identification of de novo germline mutations is possible; such mutations appear to account for cancer susceptibility in some cancer-affected young adults and children. We are also using next-generation sequencing technologies for detection of novel cancer susceptibility loci in individuals with a familial predisposition to cancer. Ultimately, the goal of our translational research is to better understand the genetic basis of cancers, which could lead to improvements in cancer risk stratification and prevention. Our current work is supported by the Damon Runyon Cancer Research Foundation, an R21 grant from the National Cancer Institute, the Starr Cancer Consortium, and Cycle for Survival.