Memorial Hospital Research Laboratories

The Richard Wong Lab

Research

Richard J. Wong,

Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and poor prognosis.

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Publications

Deborde S, Omelchenko T, Lyubchik A, Zhou Y, She S, McNamara WF, Chernichenko N, Lee SY, Barajas F, Chen CH, Bakst RL, Vakiani E, He S, Hall A, Wong RJ. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016 Mar 21. pii: 82658. doi: 10.1172/JCI82658. [Epub ahead of print]

He S, He S, Chen CH, Deborde S, Bakst RL, Chernichenko N, McNamara WF, Lee SY, Barajas F, Yu Z, Al-Ahmadie HA, Wong RJ. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Mol Cancer Res. 2015; 13: 380-90.

He S, Chen CH, Chernichenko N, He S, Bakst R, Barajas F, Deborde S, Allen P, Vakiani E, Yu Z, Wong RJ. GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. Proc Natl Acad Sci U S A. 2014; 111: E2008-17.

Bakst RL, Lee N, He S, Chernichenko N, Chen CH, Linkov G, Le HC, Koutcher J, Vakiani E, Wong RJ. Radiation impairs perineural invasion by modulating the nerve microenvironment. PLoS One. 2012; 7(6): e39925.

Gil Z, Cavel O, Kelly K, Brader P, Rein A, Gao SP, Carlson DL, Shah JP, Fong Y, Wong RJ. Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J Natl Cancer Inst. 2010; 102: 107-18.

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People

Richard J. Wong,

Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.

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Members

Sylvie Deborde
Assistant Attending Biologist – Assistant Laboratory Member

Laxmi Gusain, Research Technician — Laxmi Gusain
Research Technician

Andrea Marcadis
Clinical Research Fellow

Lab Affiliations

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Richard J. Wong discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

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