Memorial Hospital Research Laboratories

The Richard Wong Lab

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Research

Richard J. Wong,

Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and poor prognosis.

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Publications

Deborde S, Omelchenko T, Lyubchik A, Zhou Y, She S, McNamara WF, Chernichenko N, Lee SY, Barajas F, Chen CH, Bakst RL, Vakiani E, He S, Hall A, Wong RJ. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016 Mar 21. pii: 82658. doi: 10.1172/JCI82658. [Epub ahead of print]

He S, He S, Chen CH, Deborde S, Bakst RL, Chernichenko N, McNamara WF, Lee SY, Barajas F, Yu Z, Al-Ahmadie HA, Wong RJ. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Mol Cancer Res. 2015; 13: 380-90.

He S, Chen CH, Chernichenko N, He S, Bakst R, Barajas F, Deborde S, Allen P, Vakiani E, Yu Z, Wong RJ. GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. Proc Natl Acad Sci U S A. 2014; 111: E2008-17.

Bakst RL, Lee N, He S, Chernichenko N, Chen CH, Linkov G, Le HC, Koutcher J, Vakiani E, Wong RJ. Radiation impairs perineural invasion by modulating the nerve microenvironment. PLoS One. 2012; 7(6): e39925.

Gil Z, Cavel O, Kelly K, Brader P, Rein A, Gao SP, Carlson DL, Shah JP, Fong Y, Wong RJ. Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J Natl Cancer Inst. 2010; 102: 107-18.

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People

Richard J. Wong,

Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.

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Members

Chun-hao Chen, MD — Chun-hao Chen

Sylvie Deborde — Sylvie Deborde
Assistant Attending Biologist – Assistant Laboratory Member

Laxmi Gusain, Research Technician — Laxmi Gusain
Research Technician

Anna Lyubchik — Anna Lyubchik
4th year Medical Student

Andrea Marcadis — Andrea Marcadis
Clinical Research Fellow

Ann Powers — Ann Powers
Medical Student

Lab Affilations