Memorial Hospital Research Laboratories
The Richard Wong Lab
Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and poor prognosis.
Deborde S, Gusain L, Powers A, Marcadis A, Yu Y, Chen CH, Frants A, Kao E, Tang LH, Vakiani E, Amisaki M, Balachandran V, Calo A, Omelchenko T, Jessen KR, Reva B, Wong RJ. Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion. Cancer Discov. 2022; Jul 26; CD-21-1690.
Chernichenko N, Omelchenko T, Deborde S, Bakst RL, He S, Chen C-H, Gusain L, Vakiani E, Katabi N, Hall A, Wong RJ. Cdc42 mediates cancer cell chemotaxis in perineural invasion. Mol Cancer Res. 2020;18(6):913–925. PMCID: PMC7272295
Deborde S, Yu Y, Marcadis A, Chen CH, Fan N, Bakst RL, Wong RJ. An in vivo murine sciatic nerve model of perineural invasion. J Vis Exp. 2018;134:56857. PMCID: PMC5965264
Bakst RL, Xiong H, Chen CH, Deborde S, Lyubchik A, Zhou Y, He S, McNamara W, Lee SY, Olson OC, Leiner IM, Marcadis AR, Keith JW, Al-Ahmadie HA, Katabi N, Gil Z, Vakiani E, Joyce JA, Pamer E, Wong RJ. Inflammatory monocytes promote perineural invasion via CCL2-mediated recruitment and cathepsin B expression. Cancer Res. 2017;77(2):6400–6414. PMCID: PMC5831809
Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara WF, Chernichenko N, Lee SY, Barajas F, Chen CH, Bakst RL, Vakiani E, He S, Hall A, Wong RJ. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016;126(4):1538–1554. PMCID: PMC4811155
Richard J. Wong, MD, FACS
- Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.
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Richard J. Wong discloses the following relationships and financial interests:
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