Computational Image Analysis Laboratory

Overview

Binsheng Zhao
Director, Computational Imaging Analysis Lab; Member, Radiology
Lawrence H. Schwartz
Chair, Department of Radiology

The Computational Image Analysis Laboratory is dedicated to advancing cancer research and clinical practice by analyzing cancer imaging phenotypes and integrating genotypes using state-of-the-art image processing, radiomics, and deep learning techniques, with the goal of enhancing clinical decision-making in personalized precision oncology. We focus on developing and automating novel quantitative imaging biomarkers derived from CT, MRI, and PET modalities for a wide range of clinical applications, including (but not limited to) cancer surveillance, diagnosis, prognosis, and early response assessment across all solid tumors.

Key projects

  • Response Assessment Platform Integrated with Digital Volumetric Tumor Segmentation (RAPID-VTS)
  • Radiomics pipeline developed for analyzing diverse imaging phenotypes
  • Clinical validation of volumetry and kinetic modeling in tumor response assessment
  • Automated detection and segmentation of solid tumors on CT images
  • Automation of RECIST (AutoRECIST)
  • Baseline response prediction and early treatment evaluation for oncology clinical trials
  • Prostate vision-language model (VLM) to automatically generate radiology reports
  • Automated surveillance, diagnosis and response assessment for kidney cancer
  • AI-driven prediction of post-surgical recurrence in lung cancer
  • Exploring and improving the reproducibility of radiomic features and signatures
  • QA programs to ensure the accurate and reproducible quantitative imaging biomarkers
  • Data sharing efforts

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Lab members

Publications

Annotated test-retest dataset of lung cancer CT scan images reconstructed at multiple imaging parameters. Zhao B, Dercle L, Yang H, Riely GJ, Kris MG, Schwartz LH. Scientific Data 2024; 11:1259 https://doi.org/10.1038/s41597-024-04085-3.

Generalizability of lesion detection and segmentation when ScaleNAS is trained on a large multi-organ dataset and validated in the liver.  Ma J, Yang H, Chou Y, Yoon J, Allison T, Komandur R, McDunn J, Tasneem A, Do RK, Schwartz LH, Zhao B. Med Phys. 2024 Nov 22. doi: 10.1002/mp.17504. Online ahead of print.

Early Readout on Overall Survival of Patients With Melanoma Treated With Immunotherapy Using a Novel Imaging Analysis.  Dercle L, Zhao B, Gönen M, Moskowitz CS, Ahmed FS, Beylergil V, Connors DE, Yang H, Lu L, Fojo T, Carvajal R, Karovic S, Maitland ML, Goldmacher GV, and Oxnard GR, Postow MA, Schwartz LH. JAMA Oncol. 2022 Mar 1;8(3):385-392. doi:10.1001/jamaoncol.2021.6818

Deep learning for the prediction of early on-treatment response in metastatic colorectal cancer from serial medical imaging. Lu L, Dercle L, Zhao B, and Schwartz LH. Nat Commun. 2021 Nov 17;12(1):6654. doi: 10.1038/s41467-021-26990-6.

Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation. Maitland ML, Wilkerson J, Karovic S, Zhao B, Flynn J, Zhou M, Hilden P, Ahmed FS, Dercle L, Moskowitz CS, Tang Y, Connors DE, Adam SJ, Kelloff G, Gonen M, Fojo T, Schwartz LH, and Oxnard GR. Clin Cancer Res. 2020 Dec 15;26(24):6464-6474. doi: 10.1158/1078-0432.CCR-20-1493.

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People

Binsheng Zhao

Director, Computational Imaging Analysis Lab; Member, Radiology

Lawrence H. Schwartz

Chair, Department of Radiology

Members

Pengfei Geng

Senior Research Scientist

Pingzhen Guo

Senior Research Scientist

Abdalla Ibrahim

Senior Research Scientist

Nalan Karunanayake

Research Scholar

Qiyang Li

Visiting Investigator

Lin Lu

Associate Lab Member

Jingchen Ma

Assistant Lab Member

Hao Yang

Bioinformatics Software Engineer

Ping Yin

Visiting Investigator

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center