Computational Image Analysis Laboratory
Overview


The Computational Image Analysis Laboratory is dedicated to advancing cancer research and clinical practice by analyzing cancer imaging phenotypes and integrating genotypes using state-of-the-art image processing, radiomics, and deep learning techniques, with the goal of enhancing clinical decision-making in personalized precision oncology. We focus on developing and automating novel quantitative imaging biomarkers derived from CT, MRI, and PET modalities for a wide range of clinical applications, including (but not limited to) cancer surveillance, diagnosis, prognosis, and early response assessment across all solid tumors.
Key projects
- Response Assessment Platform Integrated with Digital Volumetric Tumor Segmentation (RAPID-VTS)
- Radiomics pipeline developed for analyzing diverse imaging phenotypes
- Clinical validation of volumetry and kinetic modeling in tumor response assessment
- Automated detection and segmentation of solid tumors on CT images
- Automation of RECIST (AutoRECIST)
- Baseline response prediction and early treatment evaluation for oncology clinical trials
- Prostate vision-language model (VLM) to automatically generate radiology reports
- Automated surveillance, diagnosis and response assessment for kidney cancer
- AI-driven prediction of post-surgical recurrence in lung cancer
- Exploring and improving the reproducibility of radiomic features and signatures
- QA programs to ensure the accurate and reproducible quantitative imaging biomarkers
- Data sharing efforts

Publications
Annotated test-retest dataset of lung cancer CT scan images reconstructed at multiple imaging parameters. Zhao B, Dercle L, Yang H, Riely GJ, Kris MG, Schwartz LH. Scientific Data 2024; 11:1259 https://doi.org/10.1038/s41597-024-04085-3.
Generalizability of lesion detection and segmentation when ScaleNAS is trained on a large multi-organ dataset and validated in the liver. Ma J, Yang H, Chou Y, Yoon J, Allison T, Komandur R, McDunn J, Tasneem A, Do RK, Schwartz LH, Zhao B. Med Phys. 2024 Nov 22. doi: 10.1002/mp.17504. Online ahead of print.
Early Readout on Overall Survival of Patients With Melanoma Treated With Immunotherapy Using a Novel Imaging Analysis. Dercle L, Zhao B, Gönen M, Moskowitz CS, Ahmed FS, Beylergil V, Connors DE, Yang H, Lu L, Fojo T, Carvajal R, Karovic S, Maitland ML, Goldmacher GV, and Oxnard GR, Postow MA, Schwartz LH. JAMA Oncol. 2022 Mar 1;8(3):385-392. doi:10.1001/jamaoncol.2021.6818
Deep learning for the prediction of early on-treatment response in metastatic colorectal cancer from serial medical imaging. Lu L, Dercle L, Zhao B, and Schwartz LH. Nat Commun. 2021 Nov 17;12(1):6654. doi: 10.1038/s41467-021-26990-6.
Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation. Maitland ML, Wilkerson J, Karovic S, Zhao B, Flynn J, Zhou M, Hilden P, Ahmed FS, Dercle L, Moskowitz CS, Tang Y, Connors DE, Adam SJ, Kelloff G, Gonen M, Fojo T, Schwartz LH, and Oxnard GR. Clin Cancer Res. 2020 Dec 15;26(24):6464-6474. doi: 10.1158/1078-0432.CCR-20-1493.
People



Director, Computational Imaging Analysis Lab; Member, Radiology

Chair, Department of Radiology
Members
Senior Research Scientist
Senior Research Scientist
Senior Research Scientist
Research Scholar
Visiting Investigator
Associate Lab Member
Assistant Lab Member
Bioinformatics Software Engineer
Visiting Investigator
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center