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The Shah lab focuses on the major topics of cancer evolution, single cell genomics and transcriptomics, mutational processes and prediction of drug response.

… The Shah lab focuses on the major topics of cancer evolution, single cell genomics and transcriptomics, mutational processes and prediction of drug response. We are interested in the major questions which underpin the cellular dynamics of cancer. Why do some cancer patients respond to treatment, while

Radiochemist Jason Lewis develops molecular imaging agents for the imaging and therapy of cancer.

… The Lewis lab research interests are focused on the development of radiopharmaceuticals for targeted diagnosis and treatment of cancer. By combining small- and biomolecule-based targeting agents with positron-emitting or therapeutic radioisotopes, we can interrogate molecular profiles of cancer using

Physician-Scientist A. Ari Hakimi, MD studies genetic and metabolic mechanisms of immune response in kidney cancers.

… The Hakimi Lab aims to understand immune infiltration, inflammation, and the tumor microenvironment in RCC to identify novel therapeutic targets to overcome resistance to systemic therapies. These studies apply bulk, single-cell and spatial RNA sequencing, flow cytometry, and immunogenomic analyses to

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

… Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance.  Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory

Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.

… Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, oxidative challenges,

Dr. Ahmet Dogan is a board-certified pathologist and an internationally recognized leader in hematopathology. His current research interests include lymphoma, plasma cell disorders, and diagnostic techniques for hematopathology such as cytogenetic analysis, genomics, and proteomics. His previous work has contributed much to the understanding of the histogenesis of lymphomas, MALT lymphomas, and T cell lymphomas in particular.

… The Ahmet Dogan lab within the Hematopathology Service establishes new diagnostic approaches and diagnostic test utilization algorithms, which will determine the standard of care for the hematopathology practice. The Service catalogues and analyzes the pathological features of hematological malignancies

The Gitlin Lab studies the molecular and cellular mechanisms underlying inflammatory cell signaling in health and disease.

… The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are tasked with integrating diverse molecular signals from both host and pathogen to produce appropriately commensurate inflammatory

Physician-scientist Prasad S. Adusumilli studies tumor immunology and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases.

… Research led by Prasad S. Adusumilli focuses on investigation of the tumor immune microenvironment and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases. His team has championed regional immunotherapy delivery strategies, resulting in translation of

Associate Attending Computer Scientist Harini Veeraraghavan's lab develops and translates new AI and machine learning tools diagnosing and personalizing cancer treatments through automated segmentation of normal tissues and tumors applied to radiation treatment automation, early predicting treatment response and toxicity prediction, and longitudinal tumor treatment response monitoring from medical images.

… Associate Attending Computer Scientist Harini Veeraraghavan’s lab develops and translates new AI and machine learning tools diagnosing and personalizing cancer treatments through automated segmentation of normal tissues and tumors applied to radiation treatment automation, early predicting treatment

Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.

… Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division.