Memorial Hospital Research Laboratories
The Prasad Adusumilli Lab
Research
Research led by Prasad S. Adusumilli focuses on investigation of the tumor immune microenvironment and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases. His team has championed regional immunotherapy delivery strategies, resulting in translation of mesothelin-targeted CAR T-cell immunotherapy for malignant pleural mesothelioma, lung, and breast cancers.
Cover Image from J Clin Invest Aug 1 2016. Cherkassky L, Morello A, Villena-Vargas J, Feng Y, Dimitrov DS, Jones DR, Sadelain M, Adusumilli PS. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J Clin Invest. 2016;126(8):3130-44
Cover Image from J Clin Invest Aug 1 2016. Cherkassky L, Morello A, Villena-Vargas J, Feng Y, Dimitrov DS, Jones DR, Sadelain M, Adusumilli PS. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J Clin Invest. 2016;126(8):3130-44.
Cover Image from J Thoracic Oncology Jan 2022. Gross DJ, Chintala NK, Vaghjiani RG, Grosser R, Tan KS, Li X, Choe J, Li Y, Aly RG, Emoto K, Hua Z, Dux J, Cheema W, Bott MJ, Travis WD, Isbell JM, Li BT, Jones DR, Adusumilli PS. Tumor and Tumor-Associated Macrophage PD-L1 Expression is Associated with Adjuvant Chemotherapy Benefit in Lung Adenocarcinoma. J Thorac Oncol. 2022;17(1):89-102.
Cover Image from Cancer Discovery Nov 2021. Adusumilli PS, Zauderer MG, Rivière I, Solomon SB, Rusch VW, O’Cearbhaill RE, Zhu A, Cheema W, Chintala NK, Halton H, Pineda J, Perez-Johnston R, Tan KS, Daly B, Araujo Filho JA, Ngai D, McGee E, Vincent A, Diamonte C, Sauter JL, Modi S, SikderD, Senechal B, Wang X, Travis WD, Gönen M, Rudin CM, Brentjens RJ, Jones RJ, Sadelain M. A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab. Cancer Discov. 2021;11(11):2748-2763.
Cover Image from J Thoracic Oncology Jan 2018. Kiesgen S, Chicaybam L, Chintala NK, Adusumilli PS*. Chimeric antigen receptor (CAR) T-cell therapy for thoracic malignancies. J Thorac Oncol. 2018;13(1):16-26.
Cover Image from Mol Ther Oncolytics – Vol 4, Mar 17, 2017.
Image from Science Sept 2016. Couzin-Frankel J. (2016, September 2). Second chapter. Science. 353(6303):983-5.5.
Cover Image from Cancer Immunology Research Oct 2023. Quach HT, Skovgard MS, Villena-Vargas J, Bellis RY, Chintala NK, Amador-Molina A, Bai Y, Banerjee S, Saini J, Xiong Y, Vista WR, Byun AJ, De Biasi A, Zeltsman M, Mayor M, Morello A, Mittal V, Gomez DR, Rimner A, Jones DR, Adusumilli PS. Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-cell Therapy Efficacy. Cancer Immunol Res. 2023 Oct 4;11(10):1314-1331. doi: 10.1158/2326-6066.CIR-22-0840. PMID: 37540803; PMCID: PMC10592183.
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Prasad S. Adusumilli, MD
Professor and Deputy Chief, Thoracic Service; Vice Chair for Translational Research, Dept. of Surgery; Co-Director, MSK Mesothelioma Program; Min H. and Yu-Fan C. Kao Chair in Thoracic Cancers
- Physician-scientist Prasad S. Adusumilli studies tumor immunology and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases.
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