The Prasad Adusumilli Lab
Research
Research led by Prasad S. Adusumilli focuses on investigation of the tumor immune microenvironment and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases. His team has championed regional immunotherapy delivery strategies, resulting in translation of mesothelin-targeted CAR T-cell immunotherapy for malignant pleural mesothelioma, lung, and breast cancers.
Cover Image from J Thoracic Oncology Jan 2022. Gross DJ, Chintala NK, Vaghjiani RG, Grosser R, Tan KS, Li X, Choe J, Li Y, Aly RG, Emoto K, Hua Z, Dux J, Cheema W, Bott MJ, Travis WD, Isbell JM, Li BT, Jones DR, Adusumilli PS. Tumor and Tumor-Associated Macrophage PD-L1 Expression is Associated with Adjuvant Chemotherapy Benefit in Lung Adenocarcinoma. J Thorac Oncol. 2022;17(1):89-102.
Cover Image from Cancer Discovery Nov 2021. Adusumilli PS, Zauderer MG, Rivière I, Solomon SB, Rusch VW, O’Cearbhaill RE, Zhu A, Cheema W, Chintala NK, Halton H, Pineda J, Perez-Johnston R, Tan KS, Daly B, Araujo Filho JA, Ngai D, McGee E, Vincent A, Diamonte C, Sauter JL, Modi S, SikderD, Senechal B, Wang X, Travis WD, Gönen M, Rudin CM, Brentjens RJ, Jones RJ, Sadelain M. A phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab. Cancer Discov. 2021;11(11):2748-2763.
Cover Image from Cancer Immunology Research Oct 2023. Quach HT, Skovgard MS, Villena-Vargas J, Bellis RY, Chintala NK, Amador-Molina A, Bai Y, Banerjee S, Saini J, Xiong Y, Vista WR, Byun AJ, De Biasi A, Zeltsman M, Mayor M, Morello A, Mittal V, Gomez DR, Rimner A, Jones DR, Adusumilli PS. Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-cell Therapy Efficacy. Cancer Immunol Res. 2023 Oct 4;11(10):1314-1331. doi: 10.1158/2326-6066.CIR-22-0840. PMID: 37540803; PMCID: PMC10592183.
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People
Prasad S. Adusumilli, MD
Professor and Deputy Chief, Thoracic Service; Vice Chair for Translational Research, Dept. of Surgery; Co-Director, MSK Mesothelioma Program; Min H. and Yu-Fan C. Kao Chair in Thoracic Cancers
- Physician-scientist Prasad S. Adusumilli studies tumor immunology and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases.
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Members
Achievements
- The Rodman E. Sheed and Thomas G. Sheed Awarded to Dr. Adusumilli
- Current NCI Awards Received: R01 CA235667; R01 CA236615; R01 CA292664; UG3/UH3 CA29024
- Current DoD Award Received: CA200437
- Published in the Journal Cover Pages listed below: J Clin Invest Aug 2016; Science Sept 2016; J Thorac Oncol Jan 2018; Cancer Discov Nov 2021; J Thorac Oncol Jan 2022; Cancer Immunol Res Oct 2023
