Mouse Intestinal Tissue

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VIDEO00:38

This video of mouse intestinal tissue sheds light on graft-versus-host disease. The imaging technique shows clearly for the first time that after bone marrow transplantation the invading T cells from the donor (green) go mainly to the crypt base region of the intestine (bottom of frame). The T cells cluster around areas in which there are more blood vessels expressing the MAdCAM-1 protein (light blue). (Credit: Video by Ya-Yuan Fu, courtesy of Immunity.)