Full Title
A Phase 1/2 Study of REGN4018 (Ubamatamab), a MUC16×CD3 Bispecific Antibody, Administered Alone or in Combination with Cemiplimab in Patients with Recurrent Ovarian Cancer or Other Recurrent MUC16+ CancersPurpose
The purpose of this study is to assess the safety of the investigational treatment REGN4018 alone and in combination with cemiplimab in women with ovarian, peritoneal, or fallopian tube cancer that has come back or gotten worse after previous treatment. REGN4018 is a type of drug called a bispecific antibody: it binds to two specific proteins (MUC16 and CD3) that may be involved in the growth and survival of cancer.
MUC16 is found on the cancer cells of most people who have ovarian, peritoneal, or fallopian tube cancer. CD3 is found on T cells, which are part of the immune system. Once REGN4018 finds cancer cells that have MUC16, it may help activate T cells against the cancer cells.
Cemiplimab is an immunotherapy, meaning it boosts the power of the immune system against cancer cells. It is used to treat cutaneous squamous cell carcinoma; its use in this study is considered investigational. The hope is that cemiplimab will help REGN4018 to kill cancer cells by activating the immune system. Both medications are given intravenously (by vein).