Full Title
A Phase II Study of ASTX727 in Patients with PRC2 Loss Malignant Peripheral Nerve Sheath Tumor (MPNST)Purpose
This study is assessing the safety and effectiveness of ASTX727 in people who have malignant peripheral nerve sheath tumors (MPNST) with a mutation in a gene complex called PRC2 (EED or SUZ12). ASTX727 is a combination of two drugs (cedazuridine and decitabine) that have been designed to target cancer cells with a PRC2 complex genetic mutation and disrupt the cells’ ability to survive and grow.
Researchers think that ASTX727 allows decitabine to be taken orally (by mouth) while maintaining the same effectiveness as intravenous administration (by vein). They believe that PRC2 loss may make tumors more sensitive to ASTX727. ASTX727 is already used to treat chronic myelomonocytic leukemia and myelodysplastic syndromes; its use in this study is considered investigational. ASTX727 is taken orally.