A Phase 2 Study of Selinexor in People with Wilms' Tumors and Other Solid Tumors

Full Title

A Multi-Center Phase II Study of Selinexor in Treating Recurrent or Refractory Wilms Tumor and Other Pediatric Solid Tumors

Purpose

Researchers want to see how well selinexor works in people with Wilms’ tumor and other solid tumors. The people in this study are children and adults with tumors that depend on a protein called XPO1. XPO1 helps cancer cells grow by getting rid of proteins that can cause those cells to die (tumor suppressor proteins).

Selinexor keeps XPO1 from getting rid of tumor suppressor proteins. By helping to keep tumor suppressor proteins in cancer cells, selinexor may cause those cells to stop growing or die.

This study includes people with Wilms’ tumor, rhabdoid tumors, malignant peripheral nerve sheath tumors (MPNST), and other solid tumors. Their tumors came back or keep growing even after treatment. Selinexor is taken orally (by mouth).

Contact

For more information or to see if you can join this study, please call 833-MSK-KIDS.