A Phase 1 Study of Lurbinectedin in Children With Solid Tumors

Full Title

A Phase 1/2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Recommended Phase 2 Dose (RP2D), and Efficacy of Lurbinectedin Monotherapy in Pediatric Participants with Previously Treated Solid Tumors Followed by Expansion to Assess Efficacy and Safety in Pediatric and Young Adult Participants with Relapsed/Refractory Ewing Sarcoma

Purpose

In this study, researchers are assessing the safety of the drug lurbinectedin in young people with solid tumors. In the first part, they will find the highest dose of lurbinectedin to use safely in children with solid tumors. If your child joins, this is the part of the study they will be in.

Later parts of the study will assess lurbinectedin in children and young adults with Ewing sarcoma. This cancer is a solid tumor that develops in bone or soft tissue.

Lurbinectedin is a type of drug called an alkylating agent. These medications target cancer cells and interfere with their DNA (genetic material) to slow or stop cell growth. Lurbinectedin is given intravenously (by vein).

Contact

For more information and to see if your child can join this study, please call 1-833-MSK-KIDS.