A Phase 2 Study of Datopotamab Deruxtecan Alone or With Other Anti-Cancer Drugs in People Endometrial, Ovarian, and Urothelial Cancers

Full Title

A Phase II, Multicentre, Open-label, Master Protocol to Evaluate the Efficacy and Safety of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours (TROPION-Pan Tumor 03)

Purpose

Researchers want to see how well datopotamab deruxtecan (Dato-DXd) works alone and with other drugs against cancer. The people in this study have endometrial, ovarian, or urothelial cancer that has metastasized (spread).

If you join this study, you will get Dato-DXd alone or with either volrustomig (MEDI5752) or rilvegostomig (AZD2936). All of these medications are given intravenously (by vein).

Contact

For more information or to see if you can join this study, please call Dr. Vicky Makker’s office at 646-888-4224.

Protocol
24-074
Phase
Phase II (phase 2)
Disease Status
Relapsed or Refractory
Investigator
Co-Investigators
ClinicalTrials.gov ID
NCT05489211