A Phase 2 Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia

Full Title

Prospective Randomized Phase II Study Evaluating Efficacy and Safety of IgPro20 as Infection Prophylaxis in Patients with Multiple Myeloma and Hypogammaglobulinemia Receiving Therapy with a Bispecific Monoclonal Antibody (BsAbs)

Purpose

People with multiple myeloma have a higher chance of getting infections because of the disease and its treatment. Some people who get a multiple myeloma drug called a bispecific monoclonal antibody (BsAb) develop hypogammaglobulinemia. The level of immunoglobulins in their blood is low and the risk of infection is high. Immunoglobulins are proteins made by the immune system to prevent infections.

Researchers are doing this study to see if IgPro20 can prevent infection in people with multiple myeloma who have hypogammaglobulinemia. IgPro20 works to restore low immunoglobulin levels to their normal range.

If you join this study, you will be randomly assigned to get one of these treatments:

  • IgPro20 plus standard treatment (such as antibiotics).
  • Standard treatment alone.

Contact

For more information or to see if you can join this study, please call Dr. Zainab Shahid’s office at 212-639-7810.

Protocol
24-137
Phase
Phase II (phase 2)
Disease Status
Relapsed or Refractory
Investigator
Co-Investigators
ClinicalTrials.gov ID
NCT06976476