Michael J. Mauro, MD

Before joining Memorial Sloan Kettering, I was on the faculty of Oregon Health and Sciences University for 13 years. There I directed the CML clinical trial program and was involved in the early development and sentinel clinical study of targeted therapy for CML from imatinib (Gleevec) onwards. I completed both residency and fellowship training at the NewYork-Presbyterian Hospital / Weill Cornell Medical College in Manhattan.

The treatment of myeloproliferative neoplasms (MPNs), especially CML, has seen unprecedented advance in the last 15 years. Development and approval of a number of targeted ‘kinase inhibitor’ therapies has led to the realization of long-term treatment success and a potential functional cure for CML and discovery of therapeutic targets in other MPNs. Careful decision-making is very important from diagnosis onward in MPNs given the array of options and potential for novel approaches. Areas of clinical focus for me include early optimization of therapy, understanding the basis and management of emerging side effects and managing resistance and intolerance to therapy.

Memorial Sloan Kettering has significant expertise in the molecular characterization of MPNs and a distinguished history in the development of cutting-edge effective therapies for a wide variety of leukemias. The MPN program within the Leukemia Service at Memorial Sloan Kettering Cancer Center is in an excellent position to continue research into the optimization of CML therapy and to develop new and better treatments for MPNs broadly. We have a group of clinicians focused on MPNs and an expanding clinical trials program to answer key questions and the program is dedicated to bring our patients novel therapies, best monitoring practices and long-term treatment success.