This information explains how having a mutation in the GREM1 gene may affect you and your family.
In this resource, the word “family” means family members related to you by blood. They are not related to you through marriage or adoption.
Your GREM1 gene normally helps prevent cancers. A mutation in this gene makes it stop working like it should. This increases your risk for certain types of cancers.Back to top
What’s my risk for cancer if I have a GREM1 mutation?
If you have a mutation in the GREM1 gene, this means you have a condition called Hereditary Mixed Polyposis syndrome (HMPS). HMPS increases your risk for different types of polyps (growths of tissue) in your colon and rectum. These polyps can lead to an increased risk for colorectal (colon and rectal) cancer.
For more information, read Hereditary Colon Cancer and Polyposis.
For more information, read Hereditary Colon Cancer and Polyposis - www.mskcc.org/genetics/colon-cancer-polyposis
As we learn more about this mutation, we may learn that it increases the risk for other types of cancers. Your genetic counselor will give you more information about your cancer risk if you have this mutation.
What can I do about my cancer risk if I have a GREM1 mutation?
If you have a mutation, your genetic counselor will review your results and your personal and family history of cancer and give you cancer screening recommendations.
They may recommend you start having cancer screenings at a younger age, have them more often than most people, or get specialized screenings to help find cancer as early as possible.
For example, they may recommend getting colonoscopies at an earlier age and more often than most people.
Your genetic counselor will also talk with you about whether there are any other screening or prevention options that may be right for you.Back to top
What happens if I don’t have a GREM1 mutation?
If you don’t have a mutation, your genetic counselor will review your personal and family history and talk with you about the general cancer screening guidelines you should follow.Back to top
What does a GREM1 mutation mean for my family?
If you have this mutation, your biological parents, siblings, and children each have a 50% chance of having the same mutation. This means there’s an equal chance they will or won’t have the mutation. Your distant family members may also be at risk for having the same mutation.
Males and females have an equal chance of passing down this mutation in their family. You only need to inherit this mutation from one parent to have an increased risk for cancer.
Your genetic counselor will review your family history and talk with you about whether they recommend genetic testing for your blood relatives.Back to top