This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
- It is used to treat endometrial cancer.
- It is used to treat mismatch repair deficient recurrent or advanced solid tumors.
- If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are pregnant or may be pregnant. This drug may cause harm to an unborn baby. A pregnancy test will be done before you start this drug to show that you are NOT pregnant. If you may become pregnant, you must use birth control while taking this drug and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
- If you are breast-feeding. Do not breast-feed while you take this drug or for 4 months after your last dose.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If you have constipation, diarrhea, throwing up, or upset stomach, talk with your doctor. There may be ways to lower these side effects.
- High blood sugar has happened with this drug. Check blood sugar as you have been told. Talk with the doctor if you have questions.
- Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, unusual thirst or hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Severe health problems in some organs can happen with this drug. These may happen in the bowels, lungs, liver, thyroid, pituitary, adrenal, pancreas, kidneys, or other parts of the body. Nerve problems, muscle problems, or severe skin reactions may also happen. Sometimes, these problems have been deadly. These problems may happen anytime during or after treatment with this drug. If you have questions, talk with the doctor.
- Call your doctor right away if you have signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Call your doctor right away if you have signs of kidney problems like not able to pass urine; change in how much urine is passed; bloody, brown, or foamy urine; shortness of breath or cough; or puffy or swollen face, feet, or hands.
- Call your doctor right away if you have signs of thyroid, pituitary, or adrenal gland problems. Some signs may be change in mood or the way you act, change in weight, constipation, deeper voice, dizziness, fainting, feeling cold, feeling very tired, hair loss, headache that lasts or is very bad, or lowered interest in sex.
- Call your doctor right away if you have signs of a brain problem like change in balance, feeling confused, fever, memory problems, muscle weakness, seizures, stiff neck, or very upset stomach or throwing up.
- Infusion reactions have happened with this drug. Sometimes, these could be severe or life-threatening. Tell your doctor right away if you have a rash, itching, fever or chills, shakiness, shortness of breath, wheezing, flushing, dizziness or passing out, back pain, or neck pain.
- If you have had an organ transplant, talk with your doctor. This drug may raise the chance of organ transplant rejection.
- If you are having or have had a stem cell transplant with stem cells from someone else (allogeneic), talk with your doctor. Some problems with these types of stem cell transplants have happened in people who have had this drug. These problems can be very bad and can lead to death.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of lung or breathing problems like shortness of breath or other trouble breathing, cough, or fever.
- Signs of bowel problems like black, tarry, or bloody stools; fever; mucus in the stools; throwing up blood or throw up that looks like coffee grounds; or very bad stomach pain, constipation, or diarrhea.
- Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- Signs of electrolyte problems like mood changes; confusion; muscle pain, cramps, or spasms; weakness; shakiness; change in balance; an abnormal heartbeat; seizures; loss of appetite; or severe upset stomach or throwing up.
- Signs of a severe skin reaction (Stevens-Johnson syndrome) like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes.
- Genital sores.
- Chest pain or pressure, a fast heartbeat, or an abnormal heartbeat.
- Hallucinations (seeing or hearing things that are not there).
- Very bad muscle pain or weakness.
- Fever, chills, or sore throat; any unexplained bruising or bleeding; or feeling very tired or weak.
- Swelling of the ankles.
- Change in eyesight, eye pain, or severe eye irritation.
- Swollen gland.
- Tender lumps on the skin.
- Dizziness or passing out.
- Sweating a lot.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Constipation, diarrhea, upset stomach, throwing up, or decreased appetite.
- Feeling tired or weak.
- Muscle pain.
- Dry skin.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Call your doctor to find out what to do.
- If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- This drug comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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