This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
Brand Names: US
Tryngolza
What is this drug used for?
- It is used to lower triglycerides in people with a health problem called familial chylomicronemia syndrome (FCS).
What do I need to tell my doctor BEFORE I take this drug?
- If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take this drug?
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Have your blood work and other lab tests checked as you have been told by your doctor.
- Follow the diet plan that your doctor told you about.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Do not share this product with another person. This includes any needles or syringes, even if the needle has been changed. Sharing may pass infections from one person to another. This includes infections you may not know about.
- Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Chills.
- Muscle pain.
- Low platelet counts have happened with this drug. This may lead to a higher chance of bleeding. Call your doctor right away if you have any unexplained bruising or bleeding.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Pain or redness where the injection was given.
- Joint pain.
- Joint stiffness.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
How is this drug best taken?
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into the fatty part of the skin on the top of the thigh or the belly area.
- This drug may be given into the outer area of the upper arm if given by someone else.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Before using this drug, take it out of the refrigerator and leave it at room temperature for 30 minutes.
- Do not heat or microwave.
- Do not remove the cap or cover until ready to use.
- Move the site where you give the shot with each shot.
- This drug is colorless to a faint yellow. Do not use if the solution changes color.
- Do not use if the solution is cloudy, leaking, or has particles.
- If you see small air bubbles in the device, do not try to get rid of them.
- Do not give into skin within 2 inches (5 cm) of the belly button.
- Do not give into skin that is tender, bruised, red, hard, scarred, or damaged.
- Do not use if the auto-injector is damaged.
- Each auto-injector is for 1 use only.
- Throw away any part left over after the dose is given.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do after a missed dose, call the doctor or pharmacist.
How do I store and/or throw out this drug?
- Store unopened containers in a refrigerator. Do not freeze.
- Store in the outer carton to protect from light.
- Protect from heat. Do not leave this drug at temperatures above 86°F (30°C).
- If needed, you may store at room temperature for up to 6 weeks. If stored at room temperature and not used within 6 weeks, throw this drug away.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
General drug facts
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Consumer Information Use and Disclaimer
This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.
Last Reviewed Date
2024-12-30
Copyright
© 2025 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.