This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
- A health problem called cytokine release syndrome (CRS) has happened with this drug. CRS can be severe and sometimes deadly. Call your doctor right away if you have fever or chills, signs of low blood pressure like dizziness or passing out, chest pain, fast or abnormal heartbeat, fast breathing, trouble breathing, headache, upset stomach or throwing up, or wheezing. Call your doctor right away if you feel tired, weak, anxious, or confused.
- Severe nerve problems can happen with this drug. This includes a health problem called immune effector cell-associated neurotoxicity syndrome (ICANS). Sometimes, these problems can be deadly. Call your doctor right away if you feel very sleepy, tired, or weak, or if you have a headache; abnormal burning, numbness, pain, or tingling; confusion; hallucination; trouble speaking, writing, thinking, or moving around; memory loss; muscle weakness; shakiness; or seizures.
- It is used to treat multiple myeloma.
- If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are breast-feeding. Do not breast-feed while you take this drug or for 3 months after your last dose.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Have patient safety card with you at all times.
- Avoid driving and doing other tasks or actions that call for you to be alert. Do this during the step-up dosing schedule and for 48 hours after you finish the step-up dosing schedule. You may also need to do this if you have side effects that may make you less alert. Talk with your doctor.
- Have your blood work and other lab tests checked as you have been told by your doctor.
- This drug may lower the ability of the bone marrow to make blood cells that the body needs. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. If you have questions, talk with the doctor.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Use this drug with care if you are older than 75 years of age. A study showed a higher rate of deadly side effects in patients older than 75 years of age. Talk with your doctor if you have any questions.
- This drug may cause harm to an unborn baby. A pregnancy test will be done before you start this drug to show that you are NOT pregnant.
- If you may become pregnant, you must use birth control while taking this drug and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of electrolyte problems like mood changes; confusion; muscle pain, cramps, or spasms; weakness; shakiness; change in balance; an abnormal heartbeat; seizures; loss of appetite; or severe upset stomach or throwing up.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Any unexplained bruising or bleeding.
- Change in eyesight.
- A fast heartbeat.
- Not able to pass urine or change in how much urine is passed.
- Severe skin reactions have happened with this drug. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Change in nails.
- Dry skin.
- Muscle or joint pain.
- Signs of a common cold.
- Diarrhea or constipation.
- Upset stomach.
- Irritation where the shot is given.
- Feeling tired or weak.
- It is common to have dry mouth, change in taste, trouble swallowing, mouth irritation, or mouth sores with this drug. Tell your doctor if these bother you, do not go away, or affect eating or drinking. If you lose weight while taking this drug, tell your doctor. Your doctor may have you talk to a nutritionist.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into the fatty part of the skin.
- Other drugs may be given before this drug to help avoid side effects.
- You will need to stay in the hospital for 48 hours after some doses of this drug. Talk with your doctor.
- Call your doctor to find out what to do.
- If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- This drug comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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