This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
Brand Names: US
Crixivan [DSC]
What is this drug used for?
- It is used to treat HIV infection.
What do I need to tell the doctor BEFORE my child takes this drug?
- If your child is allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.
- If your child takes any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for high cholesterol, migraines, mood problems, and others. There are many drugs that must not be taken with this drug.
- If your child is pregnant, may become pregnant, or is breast-feeding a baby. Before giving this drug to your child, you will need to talk about the benefits and risks to your child and the baby. You will also need to talk about the best way for your child to prevent passing HIV to the baby.
This is not a list of all drugs or health problems that interact with this drug.
This drug interacts with many other drugs. The chance of severe, life-threatening, or deadly side effects may be raised. Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe to give this drug with all of your child’s other drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.
What are some things I need to know or do while my child takes this drug?
- Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
- High blood sugar has happened with this drug. This includes diabetes that is new or worse.
- Check your child’s blood sugar as you have been told by the doctor.
- Some people with hemophilia have had times of more bleeding when taking drugs like this one. If your child has hemophilia, talk with the doctor.
- Have your child’s blood work and other lab tests checked as you have been told by the doctor.
- This drug may raise the chance of kidney stones. Be sure your child drinks lots of fluids while taking this drug. Children are more likely to get kidney stones than adults.
- This drug is not a cure for HIV. Keep giving this drug to your child as you have been told by the doctor or other health care provider, even if your child feels well. Be sure your child stays under the care of the doctor and has regular appointments.
- This drug helps to lower how much HIV is in the blood. Lowering the amount of HIV in the blood until it is not detected on blood tests can help lower the risk of spreading HIV to others. There are also other ways to help prevent the spread of HIV to others. This includes using condoms during sex and not sharing needles and other injection equipment. Talk with your child’s doctor or other health care provider about the best way to prevent spreading HIV to others.
What are some side effects that I need to call my child’s doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high blood sugar like confusion, feeling sleepy, unusual thirst or hunger, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Pain in side.
- Cloudy or pink-red urine.
- Bladder pain or pain when passing urine or change in how much urine is passed.
- Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.
- Change in body fat.
- Changes in your child’s immune system can happen when your child starts taking drugs to treat HIV. If your child has an infection that you did not know was there, it may show up when your child takes this drug. Tell your child’s doctor right away if your child has any new signs after starting this drug, even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
- Severe and sometimes deadly liver problems have happened with this drug. Call your child’s doctor right away if your child has signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- A very bad and sometimes deadly type of anemia called hemolytic anemia has happened with this drug. Call the doctor right away if your child has pale skin, dizziness, fever or chills, very bad back or belly pain, dark urine, yellow skin or eyes, or feels very tired or weak.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
- Headache.
- Stomach pain.
- Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.
How is this drug best given?
Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
- Give with water 1 hour before or 2 hours after a meal. However, this drug may be given with other liquids like skim milk, juice, coffee, or tea. You may also give with a light meal. This includes dry toast with jelly, juice, and coffee with skim milk and sugar, or cornflakes with skim milk and sugar. Do not give with a meal that is high in calories, fat, and protein.
- If giving this drug with ritonavir, you may give it with food.
- Have your child drink lots of noncaffeine liquids every day unless told to drink less liquid by your child’s doctor.
- Do not give didanosine within 1 hour of this drug.
- It is important that your child does not miss or skip a dose of this drug during treatment.
What do I do if my child misses a dose?
- Give a missed dose as soon as you think about it.
- If it has been 2 hours or more since the missed dose, skip the missed dose and go back to the normal time.
- Do not give 2 doses at the same time or extra doses.
- If you are not sure what to do if your child misses a dose, call the doctor.
How do I store and/or throw out this drug?
- Store at room temperature in a dry place. Do not store in a bathroom.
- Store in the original container. Do not take out the antimoisture cube or packet.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
General drug facts
- If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
- Do not share your child’s drug with others and do not give anyone else’s drug to your child.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Consumer Information Use and Disclaimer
This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.
Last Reviewed Date
2021-08-30
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