This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
- It is used to help with growth in children with achondroplasia whose bones are still growing.
- If your child is allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.
- If your child’s bones are no longer growing (closed epiphyses).
- If your child has kidney disease.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe to give this drug with all of your child’s other drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.
- Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
- Follow up with the doctor as you have been told.
- Low blood pressure may happen with this drug. To lower the risk of low blood pressure, have your child eat a meal and drink 8 to 10 ounces (240 to 300 mL) of fluid within 1 hour before getting this drug. Call the doctor if your child has symptoms of low blood pressure like dizziness, tiredness, or upset stomach.
- If your child’s weight changes, talk with the doctor. The dose of this drug may need to be changed.
If your child is pregnant or breast-feeding a baby:
- Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks to your child and the baby.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Dizziness or passing out.
- Feeling tired or weak.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
- Pain, redness, swelling, or other reaction where the injection was given.
- Throwing up.
- Joint pain.
- Stomach pain or diarrhea.
- Ear pain.
- Flu-like signs.
- Dry skin.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.
Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into the fatty part of the skin in the upper arm, thigh, buttocks, or stomach area.
- If you will be giving your child the shot, your child’s doctor or nurse will teach you how to give the shot.
- Give this drug at the same time of day.
- Move the site where you give the shot with each shot.
- This drug needs to be mixed before use. Follow how to mix as you were told by the doctor.
- If stored in a refrigerator, let this drug come to room temperature before mixing. Do not heat this drug.
- Do not shake the solution.
- After mixing, this drug may be kept in the vial at room temperature for up to 3 hours.
- Do not give into skin that is red, swollen, or tender.
- Do not give into skin within 2 inches (5 cm) of the belly button.
- Do not use if the solution is cloudy, leaking, or has particles.
- This drug is colorless to a faint yellow. Do not use if the solution changes color.
- Do not mix with any other liquid drugs.
- Throw away any part left over after the dose is given.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- Give a missed dose as soon as you think about it.
- If it is less than 12 hours until your child’s next dose, skip the missed dose and go back to your child’s normal time.
- Do not give 2 doses at the same time or within 12 hours of each other.
- Store in a refrigerator. Do not freeze.
- Store in the original container to protect from light.
- If needed, you may store at room temperature for up to 3 months. If stored at room temperature and not used within 3 months, throw this drug away.
- Do not put this drug back in the refrigerator after it has been stored at room temperature.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
- Do not share your child’s drug with others and do not give anyone else’s drug to your child.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
© 2023 UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.