Crinone; EC-RX Progesterone; Endometrin; First-Progesterone VGS 100; First-Progesterone VGS 200; First-Progesterone VGS 25 [DSC]; First-Progesterone VGS 400 [DSC]; First-Progesterone VGS 50 [DSC]; Prometrium
ACT Progesterone Injection; Crinone; Endometrin; Gesterol in Oil; PMS-Progesterone Injection; Prometrium; TEVA-Progesterone
Capsules and injection:
- Do not use estrogens with a progestin like this drug to prevent heart disease or dementia. Using estrogens with a progestin may raise the chances of having a heart attack, a stroke, breast cancer, a blood clot, or dementia.
- Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
- It is used in in vitro fertilization.
- It is used to lower the chance of endometrial changes in women after change of life who are getting estrogen therapy.
- It is used to treat uterine bleeding due to hormonal imbalance.
- It is used to treat females who do not have a monthly period cycle.
- It may be given to you for other reasons. Talk with the doctor.
- If you have an allergy to progesterone or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer; liver disease; recent heart attack; or recent stroke.
- If you have had any of these health problems: Vaginal bleeding where the cause is not known or cancer of the uterus, ovary, cervix, or vagina.
- If you have a peanut allergy and are taking the capsules. The capsules have peanut oil in them.
- If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
All other products:
- If you have had a recent miscarriage.
- If you are using any other vaginal products.
- If you have a pregnancy that is not inside the uterus (ectopic pregnancy).
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
- If you have an allergy to any type of nuts or seeds, talk with your doctor.
- If you have high blood sugar (diabetes), talk with your doctor. This drug may raise blood sugar.
- Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
- This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
- Blood clots have happened with this drug. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- If you are 65 or older, use this drug with care. You could have more side effects.
- This drug is not approved for use in children. Talk with the doctor.
- This drug may stop you from having a period (menstrual bleeding) for some time. This is not a method of birth control.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
Gel, vaginal insert, or shot:
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Chest pain or pressure.
- Shortness of breath.
- Coughing up blood.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Trouble walking.
- Very bad headache.
- Very upset stomach or throwing up.
- Very bad dizziness or passing out.
- Bulging eyes.
- Change in eyesight.
- Loss of eyesight.
- A lump in the breast, breast soreness, or nipple discharge.
- Breast pain.
- Vaginal itching or discharge.
- Vaginal bleeding that is not normal.
- Pain when passing urine.
- Passing urine more often.
- Low mood (depression).
- Mood changes.
- Memory problems or loss.
- A fast heartbeat.
- A heartbeat that does not feel normal.
- Pelvic pain.
- Feeling sleepy.
- Not able to sleep.
- More hungry.
- Hard stools (constipation).
- Pimples (acne).
- Hair loss.
- Hair growth.
- Upset stomach or throwing up.
- Belly pain.
- Loose stools (diarrhea).
- Enlarged breasts.
- Tender breasts.
- Muscle pain.
- Back pain.
- Feeling tired or weak.
- Weight gain or loss.
- Vaginal bleeding or spotting.
- Lowered interest in sex.
Gel or vaginal insert:
- Vaginal irritation.
- Irritation where the shot is given.
- Follow how to use as you have been told by the doctor or read the package insert.
- Take at bedtime if taking once a day.
- Take with or without food. Take with food if it causes an upset stomach.
- Take with a full glass of water.
- If you have trouble swallowing, talk with your doctor.
- It is given as a shot into a muscle.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Wash your hands before and after use.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not use if solution changes color.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
Gel or vaginal insert:
- Do not take this drug by mouth. For vaginal use only. Keep out of your mouth, nose, and eyes (may burn).
- Wash hands before and after use.
- Do not use the applicators more than 1 time.
- Do not take other vaginal drugs within 6 hours of this drug.
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.