Clinical Updates & Insights

Our clinical updates provide you with timely information about Memorial Sloan Kettering’s new treatment approaches, key clinical trials, and innovations in detecting and treating many cancers.

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236 Clinical Updates found
Doctor with patient
Clinical Update
Reexamining Surgical Margins in Breast Cancer

Wider negative margins do not improve local control for ductal carcinoma in situ or invasive carcinoma when they are treated with lumpectomy and radiation therapy, our recent literature review shows.
MSK Colorectal doctors
Sidestepping Rectal Cancer Surgery with Total Neoadjuvant Therapy

Total neoadjuvant therapy is a viable treatment strategy for patients with locally advanced rectal cancer and is associated with the potential to sidestep surgical treatment.
stomach illustration
The “Pocket-Creation Method” for Resecting Early-Stage Gastrointestinal Cancers

The “pocket-creation method” is the latest advance in endoscopic submucosal dissection, a technique for the removal of early-stage gastrointestinal cancers, further boosting its superiority over the standard approach of using endoscopic mucosal resection.
Daniel Prince, MD, MPH
Distraction Osteogenesis: Optimal Bone Reconstruction in Pediatric Sarcoma

Although distraction osteogenesis is commonly employed in regular orthopedic surgery, its use in cancer patients is currently limited. But research shows that these durable reconstructions can provide superior opportunities for better long-term limb function and growth in this cohort.
Jodi V. Mones, MD
Managing Chemotherapy-Induced Thrombocytopenia: Romiplostim Research

Our recent research demonstrates that the thrombopoietin receptor agonist romiplostim effectively modifies chemotherapy-induced thrombocytopenia (CIT) in solid tumor patients, allowing a majority to resume chemotherapy
Dr. Paul Chapman
Video: Good News out of ASCO 2018 on Melanoma Treatment Data

Research presented at the 2018 meeting of the American Society of Clinical Oncology showed that the relapse rate is low for melanoma patients treated with immunotherapy, but those who do relapse can respond a second time to immunotherapy. Dr. Chapman discusses the impact. (June 2018)
Vial lying on a table
Prognostic Genetic Testing Underutilized in Chronic Lymphocytic Leukemia

Prognostic genetic testing is recommended for all patients with chronic lymphocytic leukemia (CLL). However, recent research shows that testing is infrequently performed and outcomes poorer in patients with unfavorable disease risk.
Kishwer S. Nehal
Advancing Care for Complex Skin Cancers

Unlike the clinical management of other types of cancer, a multidisciplinary approach is not the established norm for treating skin cancer, resulting in significantly limited opportunities to individualize patient care.
Mark Bilsky and Ilya Laufer
Mitigating Morbidities with Modern Approaches to Spinal Metastases

Spinal cord compression due to spinal metastases is a medical emergency. Modern treatment approaches have fundamentally shifted the paradigm from providing short-term palliation and pain relief to delivering durable tumor control with fewer morbidities than older approaches. Therefore, cancer patients who have symptoms of spinal cord compression should be referred for surgical evaluation as soon as possible.
Prasad Adusumilli
CAR T Cells Show Promise in Treating Mesothelioma and Pleural Malignancies

The preliminary results of our ongoing trial investigating CAR T cell therapy to treat patients with malignant pleural disease, including mesothelioma, show “encouraging clinical outcomes”