Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80 percent of the genome contains biologically functional sequence, including thousands of long noncoding RNAs.
I am especially interested in how long noncoding RNAs control cellular behavior in response to stressors such as DNA damage and oncogene expression. My laboratory uses a combination of biochemistry, cellular biology, mouse genetics, and functional genomics to identify and characterize long noncoding RNAs involved in these processes.
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