The Adam Schmitt Lab

Until recently, the vast majority of the noncoding genome was thought be nonfunctional. Thanks to the rapid development of functional genomics, we now know that the noncoding genome is packed with a diverse array of noncoding RNAs and gene regulatory elements. Indeed, it is estimated that more than 80 percent of the genome contains biologically functional sequence, including thousands of long noncoding RNAs.

I am especially interested in how long noncoding RNAs control cellular behavior in response to stressors such as DNA damage and oncogene expression. My laboratory uses a combination of biochemistry, cellular biology, mouse genetics, and functional genomics to identify and characterize long noncoding RNAs involved in these processes.

Adam Schmitt

Adam Schmitt, MD

Research Focus

Physician-scientist Adam Schmitt studies how long noncoding RNAs regulate cellular stress responses and tumor development.


  • Schmitt AM*, Shi J*, Wolf AM, Lu CC, King LA, Zou Y. (2006). Wnt-Ryk Signaling Mediates Medial-Lateral Retinotectal Topographic Mapping. Nature. 439 (7072) pp 31-7.
  • Schmitt AM*, Crawley C*, Kang S, Raleigh D, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B. (2011). p50 (NF-kB1) is an effector protein in the cytotoxic response to DNA methylation damage. Molecular Cell. 44 (5) pp 785-96.
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