Immuno-Oncology Program

The Alan Hanash Lab

Research

Alan M. Hanash, MD, PhD
Alan M. Hanash, MD, PhD
Associate Attending Physician; Associate Member

Alan Hanash is an Associate Member of Memorial Sloan Kettering and an Attending Physician on the Adult Bone Marrow Transplant Service in the Department of Medicine. Dr. Hanash’s research focuses on the immunology of hematopoietic transplantation and immune-mediated mechanisms of tissue damage and regeneration.

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The Alan Hanash Lab

Featured News

In the Lab
This cross section of a mouse intestine shows dividing cells (stained white) in the epithelial layer of the intestine, which lines the organ. These proliferating cells help restore intestinal tissue after damage from graft-versus-host disease (GVHD).
Immune System Molecule Could Become New Treatment for Graft-Versus-Host Disease
Scientists are using a molecule from the immune system to combat this serious complication in a new way.

Publications Highlights

Ponce DM, Alousi AM, Nakamura R, Slingerland J, Calafiore M, Sandhu KS, Barker JN, Devlin S, Shia J, Giralt S, Perales MA, Moore G, Fatmi S, Soto C, Gomes A, Giardina P, Marcello L, Yan XQ, Tang T, Dreyer K, Chen J, Daley WL, Peled JU, van den Brink MRM, Hanash AM. A phase 2 study of Interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract. Blood. 2023 Mar 23; 141(12):1389-1401. PMID: 36399701. https://pubmed.ncbi.nlm.nih.gov/36399701/

Calafiore M, Fu YY, Vinci P, Arnhold V, Chang WY, Jansen SA, Egorova A, Takashima S, Kuttiyara J, Ito T, Serody J, Nakae S, Turnquist H, van Es J, Clevers H, Lindemans CA, Blazar BR, Hanash AM. A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury. Nature Communications. 2023 September 5;14(1):5411. PubMed PMID: 37669929; PubMed Central PMCID: PMC10480426; DOI: 10.1038/s41467-023-40993-5. https://pubmed.ncbi.nlm.nih.gov/37669929/

Arnhold V, Chang WY, Jansen SA, Thangavelu G, Calafiore M, Vinci P, Fu YY, Ito T, Takashima S, Egorova A, Kuttiyara J, Perlstein A, van Hoesel M, Liu C, Blazar BR, Lindemans CA, Hanash AM. Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage. JCI. 2024 Apr 1; 134(7): e155880. PubMed PMID: 38349762; PubMed Central PMCID: PMC10977993; DOI: 10.1172/JCI155880. https://pubmed.ncbi.nlm.nih.gov/38349762/

Takashima S, Sharma R, Chang W, Calafiore M, Fu YY, Jansen SA, Ito T, Egorova A, Kuttiyara J, Arnhold V, Sharrock J, Santosa E, Chaudhary O, Geiger H, Iwasaki H, Liu C, Sun J, Robine N, Mazutis L, Lindemans CA, Hanash AM. STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration. Nature Communications. 2025 Jan 2;16(1):138. PubMed PMID: 39746933; PMCID: PubMed Central PMC11697299. DOI: 10.1038/s41467-024-55227-5. https://pubmed.ncbi.nlm.nih.gov/39746933/

DeWolf S, Kuttiyara J, Vinci P, Fei T, Slingerland J, Katsamakis Z, Fein J, Gipson B, Lorenc R, Zinsmeyer V, Marcello L, Giardina P, Donohoe W, Shah G, Lin R, Papadopoulos E, Gyurkocza B, Shaffer B, Tallman M, Politikos I, Giralt S, Barker J, Perales MA, Tamari R, Abdel-Wahab O, Cho C, Hsu K, Peled JU, van den Brink MRM, Hanash AM. Bone marrow and blood demonstrate distinct immune reconstitution patterns and correlations with relapse post-transplant. Blood Advances. In press. https://pmc.ncbi.nlm.nih.gov/articles/PMC12235316/

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People

Alan M. Hanash, MD, PhD

Alan M. Hanash, MD, PhD

Associate Attending Physician; Associate Member

  • Physician-scientist Alan Hanash studies transplant immunology and immune-mediated mechanisms of tissue damage and regeneration.
  • MD, University of Miami
[email protected]
Email Address
View physician profile
Physician profile

Members

Kimon Argyropoulos
Kimon Argyropoulos
Assistant Attending
Marina Burgos da Silva
Senior Research Scientist
Marco Calafiore
Marco Calafiore
Senior Researcher
Winston Chang
Winston Chang
Graduate Student
Anastasiya Egorova
Anastasiya Egorova
Lab Manager
Ya-Yuan Fu
Ya-Yuan Fu
Senior Research Scientist
Andrea Lang Goldgewicht
Graduate Student
Rachel Lorenc
NE Medical Student
Toshihisa Satta
Research Fellow
Shuichiro Takashima
Shuichiro Takashima
Research Fellow
Gillian Lawrence
Gillian Lawrence
Research Technician
Margaret O'Connor
Margaret O'Connor
Research Technician
Diana Achaibar
Diana Achaibar
Office Coordinator
Viktor Arnhold
Viktor Arnhold
Research Fellow
Orit Ben-David
Volunteer
Niccolo Bordignon
Volunteer
Daniel Chandra
Daniel Chandra
Graduate Research Assistant
Robert Emmet
Intern
Elena Garcia-Martinez, MD
Elena Garcia-Martinez
Research Fellow
Mennah Soliman Hasheesh
Research Technician
Maheen Iqbal
Volunteer
Takahiro Ito
Takahiro Ito
Visiting Investigator
Juliet Ivanov
Juliet Ivanov
Volunteer
Suze Jansen
Suze Jansen
NE Intern
Perry Kerner
Volunteer
Jason Kuttiyara
Jason Kuttiyara
Research Technician
Anna Mertelsmann
Anna Mertelsmann
Research Fellow
Lorenzo Muranelli
Guillermo Orti
Visiting Investigator
Pranav Parsi
Intern
Johanna Pinto Lee
NE Intern
Ankita Prakash
Volunteer
Sobhana Sripada
Volunteer
Kelsey Topa
Kelsey Topa
Administrative Assistant
Murshea Tuor
Intern
Paola Vinci
Paola Vinci
Research Fellow

Achievements

  • ASCI Young Physician-Scientist Award (2014)
  • Amy Strelzer Manasevit Research Program Scholar (2014)
  • ASH Outstanding Abstract Achievement Award for Anna Mertelsmann (2013)
  • ASH Scholar Award for Junior Faculty (2012)
  • ASBMT New Investigator Award (2011)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

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Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Alan M. Hanash discloses the following relationships and financial interests:

  • American Society for Transplantation and Cellular Therapy (ASTCT)
    Professional Services and Activities
  • Evive Biotech
    Professional Services and Activities (Uncompensated)
  • Generon (Shanghai) Corporation Ltd.
    Professional Services and Activities (Uncompensated)

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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