Memorial Hospital Research Laboratories
The Andrew Kung Lab
The Kung Lab leverages patient-driven discovery to identify drivers and therapeutic vulnerabilities in pediatric and young adult cancers. The research infrastructure of the lab bridges the clinic, dry lab, and wet lab, with experimental data derived from model systems as well as in-human studies. We have developed a variety of experimental platforms to support the preclinical evaluation of promising agents including capabilities for in vitro drug screening, cell line development from patient tumor tissue, and in vivo testing in patient-derived xenograft (PDX) models. We have embraced computational biology approaches to predict genomically and non-genetically encoded tumor vulnerabilities, and utilize preclinical models to validate these therapeutic hypotheses.
O’Donohue TJ, Ibanez G, Ferreira Coutinho D, Mauguen A, Siddiquee A, Rosales N, Calder P, Ndengu A, You D, Long M, Roberts SS, Kung AL, Dela Cruz FS. Translational Strategies for Repotrectinib in Neuroblastoma. Mol Cancer Ther. 2021 Sep 4;. doi: 10.1158/1535-7163.MCT-21-0126. [Epub ahead of print]
Spitzer B, Dela Cruz FS, Ibanez Sanchez GD, Zhang Y, Xiao W, Benayed R, Markova A, Rodriguez-Sanchez MI, Bouvier N, Roshal M, Kung AL, Shukla N. ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML. Blood Adv. 2021 Apr 13;5(7):1899-1902. doi: 10.1182/bloodadvances.2020003699. PubMed Central PMCID: PMC8045514.
Slotkin EK, Diolaiti D, Shukla NN, Dela Cruz FS, Clark JJ, Gundem G, Yellapantula VD, Levine MF, You D, Ma P, Pachhal S, Ibanez Sanchez G, Benayed R, Jungbluth AA, Smyth LM, Mauguen A, Gushterova I, Ding H, Spraggon L, Darnell R, Califano A, Ladanyi M, Papaemmanuil E, Kung AL, Hyman DM, Roberts SS. Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer. Cancer Discov. 2019 May;9(5):605-616. doi: 10.1158/2159-8290.CD-18-0953. Epub 2019 Mar 15. PubMed Central PMCID: PMC6497560.
Slotkin EK, Bowman AS, Levine MF, Dela Cruz F, Coutinho DF, Sanchez GI, Rosales N, Modak S, Tap WD, Gounder MM, Thornton KA, Bouvier N, You D, Gundem G, Gerstle JT, Heaton TE, LaQuaglia MP, Wexler LH, Meyers PA, Kung AL, Papaemmanuil E, Zehir A, Ladanyi M, Shukla N. Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor. Mol Cancer Res. 2021 Jul;19(7):1146-1155. doi: 10.1158/1541-7786.MCR-20-0722. Epub 2021 Mar 22. PubMed Central PMCID: PMC8293793.
Andrew Kung, MD, PhD
Chair, Department of Pediatrics
- MD, Stanford University School of Medicine