Epidemiology & Biostatistics

The Jake Lee Lab

Research

Jake June-Koo Lee
Jake June-Koo Lee, MD, PhD
Assistant Member, Computational Oncology; Assistant Attending, Thoracic Oncology; Assistant Professor, Weill Cornell Graduate School of Medical Sciences

The Lee Lab focuses on understanding how cancer genomes evolve under therapeutic pressure, with an emphasis on the origins, structure, and functional impact of genomic rearrangements. By integrating high throughput sequencing data from patient derived samples and experimental models, the lab develops computational approaches to map DNA double strand breaks, their repair mechanisms, and the resulting clonal trajectories over time. Through these efforts, the Lee Lab aims to translate fundamental insights into cancer genome dynamics into strategies that can better constrain tumor evolution and improve therapeutic outcomes.

Publications Highlights

Watson E*, Lee JJ*, Gulhan DC, Melloni GEM, Venev SV, Magesh RY, Frederick A, Chiba K, Wooten EC, Naxerova K, Dekker J, Park PJ†, Elledge SJ†. Chromosome evolution screens select tissue-specific tumor aneuploidy patterns. Nature Genetics. 2024 May;56(4):900-912. [PMID 38388848]

 Lee JJ†, Jung YL, Cheong TC, Valle-Inclan JE, Chu C, Gulhan DC, Ljungstrom V, Jin H, Viswanadham V, Watson EV, Cortes-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJ†. ERɑ-associated translocations underlie oncogene amplifications in breast cancer. Nature. 2023 Jun;618(7967):1024-1032. [PMID 37198482]

 Lee JJ*, Park S*, Park H, Kim S, Lee J, Lee J, Youk J, Yi K, An Y, Park IK, Kang CH, Chung DH, Kim TM, Jeon YK, Hong D, Park PJ, Ju YS†, Kim YT†. Tracing oncogene rearrangements in the mutational history of lung adenocarcinoma. Cell. 2019 Jun 13;117(7):1842-1857. [PMID 31155235]

Lee JK, Lee J, Kim S, Kim S, Youk J, Park S, An Y, Keam B, Kim DW, Heo DS, Kim YT, Kim JS, Kim SH, Lee JS, Lee SH, Park K, Ku JL, Jeon YK, Chung DH, Park PJ, Kim J, Kim TM†, Ju YS†. Clonal history and genetic predictors of transformation into small cell carcinomas from lung adenocarcinomas. Journal of Clinical Oncology. 2017 Sep 10;35(26):3065-3074. [PMID 28498782]

Lee JK*, Hahn S*, Kim DW†, Suh KJ, Keam B, Kim TM, Lee SH, Heo DS. Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small-cell lung cancer harboring wild-type epidermal growth factor receptor: a meta-analysis. JAMA – Journal of American Medical Association. 2014 Apr;311(14):1430-1437. [PMID 24715074]

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People

Jake June-Koo Lee

Jake June-Koo Lee, MD, PhD

Assistant Member, Computational Oncology; Assistant Attending, Thoracic Oncology; Assistant Professor, Weill Cornell Graduate School of Medical Sciences

  • We study mutational processes that drive cancer evolution and treatment resistance.
[email protected]
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