The James Fagin Lab

The focus of our work is to understand the pathogenesis and the biology of thyroid cancers with the goal of identifying new molecular-based therapies. Thyroid cancer is the most common endocrine malignancy. Exposure to radiation during childhood confers increased predisposition to this disease. Our lab has been instrumental in characterizing many of the somatic genetic changes associated with thyroid tumor initiation and progression in both radiation-induced and sporadic thyroid cancer, and in defining the functional consequences using in vitro and in vivo experimental models.