Memorial Hospital Research Laboratories
The Jian Carrot-Zhang Lab
The Carrot-Zhang Lab started in 2022. We focus on developing cutting-edge computational methods to link the germline genome to the specific somatic phenotypes, in order to better characterize cancer risk and response to treatment mechanisms. Another focus of the lab is combining statistical modeling and large-scale, multiethnic clinical genomic cohorts to understand how cancer is impacted by genetic ancestry, with the goal of improving precision oncology for all. The group is also involved in Project GENIE (Genomics Evidence Neoplasia Information Exchange), a collaboration with The Cancer Genome Atlas (TCGA) and the American Association for Cancer Research (AACR), and has a strong interest in discovering new cancer drivers through whole-genome sequencing. More information about our research is available here.
Nassar AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J, Gusev A. Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors. Cancer Cell. 2022 Oct 10;40(10):1161-1172.e5. doi: 10.1016/j.ccell.2022.08.022. Epub 2022 Sep 29. PMID: 36179682; PMCID: PMC9559771.
Barry-Hundeyin M, Carrot-Zhang J, Dayton T, Ghazanfar S, Guenther LM, Nguyen DTT, Pitarresi JR, Rajput S, Santana-Codina N, Shree T, Zeng Z, Zhang Y. The 2022 generation. Nat Cancer. 2022 Dec;3(12):1426-1431. doi: 10.1038/s43018-022-00481-z. PMID: 36539504.
Mukherjee S, Carrot-Zhang J. Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants. Cancer Cell. 2022 Oct 10;40(10):1081-1083. doi: 10.1016/j.ccell.2022.09.006. Epub 2022 Sep 29. PMID: 36179687.
Arora K, Tran TN, Kemel Y, Mehine M, Liu YL, Nandakumar S, Smith SA, Brannon AR, Ostrovnaya I, Stopsack KH, Razavi P, Safonov A, Rizvi HA, Hellmann MD, Vijai J, Reynolds TC, Fagin JA, Carrot-Zhang J, Offit K, Solit DB, Ladanyi M, Schultz N, Zehir A, Brown CL, Stadler ZK, Chakravarty D, Bandlamudi C, Berger MF. Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort. Cancer Discov. 2022 Nov 2;12(11):2552-2565. doi: 10.1158/2159-8290.CD-22-0312. PMID: 36048199; PMCID: PMC9633436.
Carrot-Zhang J, Han S, Zhou W, Damrauer JS, Kemal A; Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R. Analytical protocol to identify local ancestry-associated molecular features in cancer. STAR Protoc. 2021 Sep 20;2(4):100766. doi: 10.1016/j.xpro.2021.100766. PMID: 34585150; PMCID: PMC8456058.
Jian Carrot-Zhang, PhD
GSK Faculty Member
- Computational Geneticist focused on germline-somatic interaction in multi-ethnic populations.
- Postdoc: Dana-Farber Cancer Institute and Broad Institute
- PhD, McGill University
- Instructor, Harvard Medical School
- National Cancer Institute – K99 Pathway to Independence Award, “Understanding ancestral contribution to lung adenocarcinoma.” (Role: PI) (2021)
- Banting Postdoctoral Fellowships Award, Canadian Institutes of Health Research (2019)
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Computational Postdocs and Graduate Students
We are actively recruiting computational postdocs and graduate students interested in genetic ancestry, germline-somatic interaction and clinical genomics. Please send your CV to [email protected]