Epidemiology & Biostatistics

The Jian Carrot-Zhang Lab

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Research

Jian Carrot-Zhang
Jian Carrot-Zhang, PhD
Assistant Attending

The Carrot-Zhang Lab, established in 2022, focuses on developing cutting-edge computational methods to link the germline genome to somatic phenotypes. Our goal is to better characterize cancer risk and response to treatment mechanisms through germline-somatic interaction analysis. Another key focus of our lab is combining statistical modeling and large-scale, clinical genomic cohorts to understand how cancer is impacted by genetic ancestry, with the aim of improving precision oncology for all. Our group is actively involved in Project GENIE (Genomics Evidence Neoplasia Information Exchange), a collaboration with The Cancer Genome Atlas (TCGA) and the American Association for Cancer Research (AACR). We have a strong interest in discovering new cancer drivers through whole-genome sequencing. More information about our research is available here.

Publications Highlights

Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers. Jiagge E, Jin DX, Newberg JY, Perea-Chamblee T, Pekala KR, Fong C, Waters M, Ma D, Dei-Adomakoh Y, Erb G, Arora KS, Maund SL, Njiraini N, Ntekim A, Kim S, Bai X, Thomas M, van Eeden R, Hegde P, Jee J, Chakravarty D, Schultz N, Berger MF, Frampton GM, Sokol ES, Carrot-Zhang J. Cancer Cell. 2023 Nov 13;41(11):1963-1971.e3. Epub 2023 Oct 26. PMID: 37890492.

Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors. AH, Adib E, Abou Alaiwi S, El Zarif T, Groha S, Akl EW, Nuzzo PV, Mouhieddine TH, Perea-Chamblee T, Taraszka K, El-Khoury H, Labban M, Fong C, Arora KS, Labaki C, Xu W, Sonpavde G, Haddad RI, Mouw KW, Giannakis M, Hodi FS, Zaitlen N, Schoenfeld AJ, Schultz N, Berger MF, MacConaill LE, Ananda G, Kwiatkowski DJ, Choueiri TK, Schrag D, Carrot-Zhang J*, Gusev A*. Cancer Cell. 2022 Oct 10;40(10):1161-1172.e5. Epub 2022 Sep 29. PMID: 36179682; PMCID: PMC9559771.

Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations. Carrot-Zhang J, Soca-Chafre G, Patterson N, Thorner AR, Nag A, Watson J, Genovese G, Rodriguez J, Gelbard MK, Corrales-Rodriguez L, Mitsuishi Y, Ha G, Campbell JD, Oxnard GR, Arrieta O, Cardona AF, Gusev A, Meyerson M. Cancer Discov. 2021 Mar;11(3):591-598. Epub 2020 Dec 2. PMID: 33268447; PMCID: PMC7933062.

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer. Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E; Cancer Genome Atlas Analysis Network; Cherniack AD, Beroukhim R. Cancer Cell. 2020 May 11;37(5):639-654.e6.PMID: 32396860; PMCID: PMC7328015.

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. Witkowski L*, Carrot-Zhang J*, Albrecht S, Fahiminiya S, Hamel N, Tomiak E, Grynspan D, Saloustros E, Nadaf J, Rivera B, Gilpin C, Castellsagué E, Silva-Smith R, Plourde F, Wu M, Saskin A, Arseneault M, Karabakhtsian RG, Reilly EA, Ueland FR, Margiolaki A, Pavlakis K, Castellino SM, Lamovec J, Mackay HJ, Roth LM, Ulbright TM, Bender TA, Georgoulias V, Longy M, Berchuck A, Tischkowitz M, Nagel I, Siebert R, Stewart CJ, Arseneau J, McCluggage WG, Clarke BA, Riazalhosseini Y, Hasselblatt M, Majewski J, Foulkes WD.Nat Genet. 2014 May;46(5):438-43. Epub 2014 Mar 23. PMID: 24658002.

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People

Jian Carrot-Zhang

Jian Carrot-Zhang, PhD

Assistant Attending

  • Computational Geneticist focused on germline-somatic interaction in multi-ethnic populations.
  • Postdoc: Dana-Farber Cancer Institute and Broad Institute
  • PhD, McGill University
  • Instructor, Harvard Medical School
[email protected]
Email Address
646-608-7645
Office Phone

Members

Tejiri Agbamu

GSK Graduate Student

Setor Amuzu

Henry and Alexia Fernandez Fellow

Xuechun Bai

Computational Biologist I

Nikolaos Dimitriou

Postdoctoral Fellow

David Ma
David Ma

Computational Biologist I

Leah Morales

Graduate Student

Tomin Perea-Chamblee
Tomin Perea-Chamblee

Bioinformatics Software Engineer

Zi Jin Cheryl Phua
Zi Jin Cheryl Phua

Graduate Student

Genesis Pineda
Genesis Pineda

Project Coordinator

Afsana Rahman
Afsana Rahman

Graduate Student- Tri-I Program

Hanxiao Sun
Hanxiao Sun

Postdoctoral Fellow

Lab Alumni
Xinran Bi

Summer Intern, now Graduate Student at Princeton University

Kelly Pekala

Former Clinical Fellow, now a Urologist in MultiCare Urology Puyallup

Lab Affiliations

Achievements

  • National Cancer Institute – K99 Pathway to Independence Award, “Understanding ancestral contribution to lung adenocarcinoma.” (Role: PI) (2021)
  • Banting Postdoctoral Fellowships Award, Canadian Institutes of Health Research (2019)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Computational Postdocs and Graduate Students

We are actively recruiting computational postdocs and graduate students interested in genetic ancestry, germline-somatic interaction and clinical genomics. Please send your CV to [email protected]

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Jian Carrot-Zhang discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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