Memorial Hospital Research Laboratories

The Karlo Perica Lab

Research

Karlo Perica
Karlo Perica, MD, PhD

The laboratory of Dr. Karlo Perica focuses on developing new Chimeric Antigen Receptor T cell and other cell therapies for cancer. We seek to make cell therapy more accessible and more effective by developing “off-the-shelf” approaches using allogeneic cell therapies and in vivo editing.

Our research spans the scientific spectrum from basic studies in animal models, to translational and correlative work with patient samples, to development of new cell therapy products. Ongoing projects include developing allogeneic cells that resist immune rejection, gene editing of CAR T cells to enhance potency and function, translational research on the correlates of CAR T cell response in patients, and in vivo gene editing of T cells.

Research Projects

Karlo Perica Lab group photo

Publications Highlights

HIV immune evasin Nef enhances allogeneic CAR T cell potency.

Perica K, Kotchetkov IS, Mansilla-Soto J, Ehrich F, Herrera K, Shi Y, Dobrin A, Gönen M, Sadelain M.Nature. 2025 Apr;640(8059):793-801. doi: 10.1038/s41586-025-08657-0. Epub 2025 Jan 30.PMID: 39884316

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53.

Perica K, Jain N, Scordo M, Patel R, Eren OC, Patel U, Gundem G, Domenico D, Mitra S, Socci ND, Everett JK, Roche AM, Petrichenko A, Shah GL, Arcila ME, Borsu L, Park JH, Horwitz SM, Giralt SA, Dogan A, Leslie C, Papaemmanuil E, Bushman FD, Usmani SZ, Sadelain M, Mailankody S.N Engl J Med. 2025 Feb 6;392(6):577-583. doi: 10.1056/NEJMoa2411507.

Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies.

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People

Karlo Perica

Karlo Perica, MD, PhD

  • Physician-scientist Karlo Perica develops cell therapies to treat a wide variety of cancers, focusing on off-the-shelf approaches such as allogeneic CAR T cells and in vivo gene editing.
[email protected]
Email Address

Members

Kevin Herrera
Senior Research Technician
Kimberly Lucero
Research Scholar
Ana Marie Perea
GSK Graduate Student
Kristin Singh
Kristin Singh
Research Scholar

Open Positions

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Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Karlo Perica discloses the following relationships and financial interests:

  • NexImmune
    Intellectual Property Rights
  • Pfizer, Inc.
    Professional Services and Activities
  • RxCure LLC
    Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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